CLINICAL, MICROBIOLOGY CHARACTERISTICS AND RESULTS OF TREATMENT OF PATIENT WITH UROSEPSIS AT DEPARTMENT OF EMERGENCY – HANOI MEDICAL UNIVERSITY HOSPITAL
Main Article Content
Abstract
Objectives: To evaluate the clinical, microbiological characteristics and treatment results of patients with urosepsis admitted to the emergency department at Hanoi Medical University Hospital. Methods: Cross-sectional descriptive. Results: There were 44 patients, 56.8% (25/44) female; average age: 66.98 ± 14.51 (26 – 94); 59.1% (26/44) are aged ≥ 65; 26/44 (59.1%) had shock; average SOFA score: 5.8 ± 2.95, average APACHE II score: 15.36 ± 4.19. As a result, 29/44 (65.9%) blood or urine samples isolated pathogenic bacteria, of which 27/29 (93.1%) were gram-negative bacteria, the most common bacteria being Escherichia Coli. 18/29 (62.07%). The rate of resistance to carbapenem antibiotics is 0-11.1%, aminoglycosisde is 3.7-14.8%. The hospital mortality rate of patients with urosepsis was 5/44 (11.36%). Conclusion: The majority of urosepis patients entered the emergency department in shock. 65.9% of blood and urine samples isolated pathogenic bacteria, mainly Escherichia Coli, which were sensitive to carbapenem and aminoglycoside antibiotics. The in-hospital mortality rate of urosepsis patients was 11.36%.
Article Details
Keywords
sepsis, urosepsis, septic shock, urinary tract infection, percutaneous pyelonephritis
References
2. Rello J, Valenzuela-Sánchez F, Ruiz-Rodriguez M, Moyano S. Sepsis: A Review of Advances in Management. Advances in Therapy. 2017/11/01 2017;34(11):2393-2411. doi: 10.1007/s12325-017-0622-8
3. Reinhart K, Daniels R, Kissoon N, Machado FR, Schachter RD, Finfer S. Recognizing Sepsis as a Global Health Priority — A WHO Resolution. New England Journal of Medicine. 2017; 377(5):414-417. doi:10.1056/NEJMp1707170
4. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet. 2020/01/18/ 2020;395(10219):200-211. doi: https://doi.org/10.1016/S0140-6736(19)32989-7
5. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama. 2016;315(8):801-810.
6. Peters-Sengers H, Butler JM, Uhel F, et al. Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study. Intensive Care Med. Jan 2022; 48(1):92-102. doi:10.1007/s00134-021-06574-0
7. Álvaro-Meca A, Jiménez-Sousa MA, Micheloud D, et al. Epidemiological trends of sepsis in the twenty-first century (2000–2013): an analysis of incidence, mortality, and associated costs in Spain. Population Health Metrics. 2018/02/12 2018;16(1):4. doi:10.1186/s12963-018-0160-x
8. Ogura H, Gando S, Saitoh D, et al. Epidemiology of severe sepsis in Japanese intensive care units: A prospective multicenter study. Journal of Infection and Chemotherapy. 2014/03/01/ 2014;20(3):157-162. doi: https://doi.org/10.1016/j.jiac.2013.07.006
9. Xie J, Wang H, Kang Y, et al. The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey. Critical Care Medicine. 2020;48(3):e209-e218. doi: 10.1097/ccm.0000000000004155
10. Complicated Urinary Tract Infections: Developing Drugs for Treatment (June 2018).
11. Sheng Y, Zheng W-l, Shi Q-f, Zhang B-y, Yang G-y. Clinical characteristics and prognosis in patients with urosepsis from intensive care unit in Shanghai, China: a retrospective bi-centre study. BMC Anesthesiology. 2021/11/27 2021; 21(1):296. doi:10.1186/s12871-021-01520-5
12. Tandogdu Z, Bartoletti R, Cai T, et al. Antimicrobial resistance in urosepsis: outcomes from the multinational, multicenter global prevalence of infections in urology (GPIU) study 2003-2013. World J Urol. Aug 2016;34(8):1193-200. doi:10.1007/s00345-015-1722-1