ĐẶC ĐIỂM LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ CÁC KHỐI U NGUYÊN BÀO VÕNG MẠC TRÊN CÁC MẮT ĐƯỢC ĐIỀU TRỊ BẢO TỒN NHÃN CẦU

Abstract

Purpose: To describe charateristics intra ocular retinoblastoma tumors and outcomes of conservation treatment. Methods: Noncomparative interventional case series 100 tumors in 48 consecutive eyes of 43 patients. were classified according to the ICRB. Results: mean age: 15,7 ± 12,8 months old (youngest was 1 month old). The results of discovery retinoblastoma for conservation treatment were mostly by fundus screening 35/43 patients (81,3%), bilateral retinoblastoma were 38/43 patients. Total 100 tumors in 48 eyes of 43 RB patients with  mean 2,3 ± 1,67 tumors /eye (1-7 tumors). Tumor  base diameter meand 5,8 ± 5,2mm (1 - 21mm) and thickness mean 3,5 ± 3,4mm (1 - 15mm), the mean follow-up was 14,8 months (range: 6 - 48 months). Mean time of new tumors was 6,6 ± 3,9 months (1- 15 months of follow-up) and mean time of recurrent tumors was 11 months (1-17 months of follow-up). 32/100 tumors had been treated by focal treatment( laser/cryo) and 68/100 tumors with intravenous chemotherapy. Result: tumor base diameter mean decrease 3,41 ± 2,70 mm and thickness mean decrease in 1,97 ± 2,04 mm/u (p <0,01 – paired sample T-test). There were 85/100 tumors regressed with good results 70%, recurrent in 15% and not control in 15%. With time of follow-up, the regression pattern type 2,3 had been transferred to type 1,4. At the end of rasearch, the type 4 had maximum (64%), next type 1(16%), type 2 (3%) and type 3 (2%) (p<0,01).  Conclusion: Intraocular retinoblastoma tumors could well treated with focal treatment (laser or cryotherapy) or combine with intravenous chemotherapy. However, the tumors had been regressed by 5 different types, change by time follow-up and most regression patterns are type 1 and 4.