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Date Published: 24/03/2023
Abstract Views: 253
Views PDF: 117
DOI: https://doi.org/10.51298/vmj.v524i1B.4737
Issue
Vol. 524 No. 1B (2023)
Section
Các bài báo
How to Cite
Vũ , T. T. ., Trần , T. P. M. ., & Nguyễn, K. S. . (2023). EFFECT OF SPERM DNA FRAGMENTION ON IVF/ICSI OUTCOMES. Vietnam Medical Journal, 524(1B). https://doi.org/10.51298/vmj.v524i1B.4737

EFFECT OF SPERM DNA FRAGMENTION ON IVF/ICSI OUTCOMES

Thị Tuất Vũ 1,, Thị Phương Mai Trần 2, Khang Sơn Nguyễn3
1 Kien an hospital
2 Hanoi medical university
3 Hanoi medical university hospital

Main Article Content

Abstract

Objective: To evalate the relationship between the degree of DNA damage sperm (DFI- DNA fragmentation index) with IVF/ICSI results of 82 infertile couples. Subjects and research methods: A prospective cohort study of 82 infertile couples undergoing treatment at Reproductive Support Center of Ha Noi Medical University Hospital from August 2020- December 2021. The husband was tested for semen analysis and confirmed by DFI test determine the degree of DNA fragmentation by Halosperm test on the day of egg retrieval, wife was fresh embryo transfered (ET) or frozen embryo transfered (FET). Results: Fertilization rate of N3 group (with DFI ≥ 30%) is the lowest, lower than N2 group (with DFI from 15% to 30%) with P = 0.036. In N3 group: The percentage of good embryos ≥ 30% is lower than the percentage of good embryos < 30% and this distribution is also different from N2, N1, statistically significant with p=0.04. DFI is positively correlated with rate of bad embryos, r = 0.288; p= 0.009. The estimated equation is as follows: CLPX= 0.288*DFI, statistically significant with P= 0.009. Implantation rate, pregnancy rate, clinical pregnancy rate in N1 (with DFI <15%), N2 higher than N3, p> 0.05. Conclusion: DFI has a correlation with embryo quality, high DFI reduces ferilization rate, p< 0.05. There is no relationship between DFI and implantation rate, pregnancy rate, clinical pregnancy rate in IVF/ICSI.

Article Details

Keywords

Halosperm test, DFI- DNA fragmentation index, IVF/ICSI outcomes

References

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