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Date Published: 24/03/2023
Abstract Views: 299
Views PDF: 327
DOI: https://doi.org/10.51298/vmj.v524i1B.4780
Issue
Vol. 524 No. 1B (2023)
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Chu , L. H. ., Nguyễn, T. V. ., & Nguyễn, T. Q. N. (2023). THE EFFECT OF SURFACTANT REPLACEMENT THERAPY ON TREATMENT OF NEONATAL RESPIRATORY DISTRESS DUE TO MECONIUM ASPIRATION SYNDROME. Vietnam Medical Journal, 524(1B). https://doi.org/10.51298/vmj.v524i1B.4780

THE EFFECT OF SURFACTANT REPLACEMENT THERAPY ON TREATMENT OF NEONATAL RESPIRATORY DISTRESS DUE TO MECONIUM ASPIRATION SYNDROME

Lan Hương Chu 1,2,, Thị Vân Nguyễn1,2, Thị Quỳnh Nga Nguyễn1,2
1 Vietnam National Children's Hospital.
2 Hanoi medical university

Main Article Content

Abstract

Meconium aspiration syndrome (MAS) is respiratory distress in neonates caused by the presence of meconium in the airway. Surfactant inactivation is an important component of the pathogenesis of MAS. The study was conducted in 48 patients with severe MAS. All the patients were instilled with poractant alfa via endotracheal tube with dosage of 100 mg/kg. The changes in mechanical ventilation settings and oxygenation were noted 1 hour, 4 hours, 12 hours, 24 hours, 48 hours and 72 hours after surfactant installation. The boy to girl ratio was 1.67. The mean gestational age was 39,1 ± 1,3 weeks. The mean birth weight was 3290 ± 395 grams. There was an increase in SpO2 and PaO2 in contrast to a decrease  in OI and AaDO2 after surfactant when compared to before surfactant. The change in MAP was not significant. The death rate in this study was 27.1%.

Article Details

Keywords

suy hô hấp, hội chứng hít phân surfactant, trẻ sơ sinh

References

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