Article Sidebar

PDF
Date Published: 27/04/2023
Abstract Views: 238
Views PDF: 82
DOI: https://doi.org/10.51298/vmj.v525i2.5178
Issue
Vol. 525 No. 2 (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. B. ., & Nguyễn, T. T. . (2023). CHARACTERISTICS OF PERIPHERAL BLOOD T LYMPHOCYTE AND SUBSETS, B LYMPHOCYTE AND NATURAL KILLER (NK) CELL IN CHILDREN WITH PNEUMONIA. Vietnam Medical Journal, 525(2). https://doi.org/10.51298/vmj.v525i2.5178

CHARACTERISTICS OF PERIPHERAL BLOOD T LYMPHOCYTE AND SUBSETS, B LYMPHOCYTE AND NATURAL KILLER (NK) CELL IN CHILDREN WITH PNEUMONIA

Thanh Bình Nguyễn1,2,, Thị Thanh Nguyễn3
1 Hanoi medical university
2 Vietnam National Children's Hospital.
3 Thanh Hoa Medical College

Main Article Content

Abstract

Object: To evaluate the change of peripheral blood T lymphocyte and subsets, B lymphocyte and natural killer (NK) cell in children with pneumonia. Subject and Method: A cross-sectional study on 192 patients with pneumonia from 0 – 60 mo in National Children’s Hospital. The number of T lymphocyte and subsets, B lymphocyte and NK cells were evaluated by flowcytometry on BD FACS Canto-II device using BD Multitest 6 color TBNK Kit. Result: The percentage of patient with decrease of peripheral blood T lymphocyte count is 24.48%, decreased percentage of TCD4 cell count is 36.46%. While percentage of TCD8 cell count is increased in 28.13% in all patients. However, the patients with increased TCD8 cell count almost related to pneumonia by virus, rare with pneumonia by bacteria, The percentage of B lymphocyte count and NK cell count are not clearly change in children with pneumonia.

Article Details

Keywords

Lymphocyte, NK cell, Pneumonia, National Children’s Hospital

References

1. Bài giảng Miễn dịch học (2005). Nhà xuất bản Y học.
2. Lê Văn Tráng (2020). Nghiên cứu căn nguyên gây bệnh và yếu tố nguy cơ ở trẻ bị viêm phổi kéo dài trên 2 tuần tại khoa hô hấp Bệnh viện nhi Thanh Hóa. Tạp chí nghiên cứu và thực hành Nhi khoa. Số 1, 58-64.
3. Nguyễn Thị Hà và CS (2020). Đặc điểm lâm sàng và căn nguyên vi khuẩn gây viêm phổi cộng đồng trẻ em tại khoa Quốc tế Bệnh viện Nhi Trung ương. Tạp chí nghiên cứu Y học, 131 (7), 67-73.
4. Dagan R, Phillip M, Sarov I et al (1987). Cellular immunity and T-lymphocyte subsets in young children with acute measles. J Med Virol, 22(2), 175-182.
5. Eman M. Saleh, Nidhal Abdul Mohymen, Majed Al-Jelawy (2008). Abnormal Lymphocyte Subsets in Children With Type 1 Diabetes Mellitus. MMJ, 1, 9-14.
6. Erwin W. Gelfand, Anthony Joetham, Meiqin Wang et al (2017). Spectrum of T-lymphocyte activities regulating allergic lung inflammation. Immunol Rev, 278(63-86.
7. Jonathan S Boomer, Jonathan M Green, Richard S Hotchkiss (2014). The changing immune system in sepsis. Is individualized immuno-modulatory therapy the answer? Virulence, 5(1), 45-56.
8. Kayser W, Spiegel K, Schmitz N et al (1987). Application of a microseparation technique allowing for extensive marker studies on small bone marrow specimens. Journal of immunological methods, 97(2), 245-249.
9. Levandowski RA, Ou DW, Jackson GG (1986). Acute-phase decrease of T lymphocyte subsets in rhinovirus infection. J Infect Dis, 153(4), 743-748.