ĐÁNH GIÁ HIỆU QUẢ CAN THIỆP CỦA DƯỢC SĨ LÊN VIỆC THEO DÕI TRỊ LIỆU VANCOMYCIN TẠI KHOA HỒI SỨC TÍCH CỰC – CHỐNG ĐỘC, BỆNH VIỆN NGUYỄN TRI PHƯƠNG

Abstract

Objective: Evaluating the effectiveness of the pharmacist’s interventions for applying TDM vancomycin guidelines at the Intensive Care Unit - Anti-Poison, Nguyen Tri Phuong Hospital. Subjects and methods: Retrospectively reviewed 82 medical records with TDM vacomycin, of which 40 were in the period without a clinical pharmacist (before the intervention from 3/2020 to 8/2020) and 42 in the period with a clinical pharmacist working at the Intensive Care Unit - Anti-poison (intervention from 9/2020 to 2/2021). Results: The rate of adherence to dose adjustment according to the TDM guide increased from 60.6% to 79.2%, the difference was statistically significant, p = 0.019. The percentage of samples with trough concentrations reaching the treatment target increased from 26.7% to 42.0%, the difference was statistically significant, p=0.036. The proportion of patients with at least one trough concentration in the target range increased from 35.0% to 57.1%, the difference was statistically significant, p=0.039. The length of hospital stay decreased from 28.6 days to 22.5 days, the difference was not statistically significant. Conclusions: Implementation of Vancomycin TDM Guide with clinical pharmacist’s intervention increases the rate of samples reaching therapeutic target concentrations, and increases the rate of patient reaches the target concentration.