PHÂN TÍCH HIỆU QUẢ CAN THIỆP CỦA CHƯƠNG TRÌNH QUẢN LÝ SỬ DỤNG KHÁNG SINH COLISTIN TẠI BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC

Abstract

Objective: The Viet Duc University Hospital has implemented the Prescribing Guidance for colistin in the antimicrobial stewardship program since June 2022, therefore this study was aimed at analyzing the effectiveness of the program. Subject and method: The use of colistin was evaluated based on retrospective medical records between April and June, 2021, and prospectively follow-up of patients that having order form of colistin with interventions by clinical pharmacists from August to October, 2022. Results: All 201 order forms of colistin were approved for use by clinical pharmacists within 3 months. A total of 253 interventions were carried out with overall acceptance rate of 52.2%. Colistin has been indicated by physicians for severe infections caused by multi-resistant bacteria. The concordance rate for indications in the two study periods was not significantly different and was relatively high (99.2% and 100.0%, respectively). The rate of administration loading dose, loading dose, maintenance dose, and monitoring of renal function in accordance with the Guideline improved significantly, with a rate of 77.3%, 20.5%, 26.5%, and 53.0% in pre-intervention compared to 99.5%,70.1%, 63.1%, and 72.6% in the intervention period (p<0.001). Most of the dosing was not suitable related to lower than recommended. Conclusion: These results revealed the positive impact of interventions for the use of colistin and the need for training and communication among healthcare workers to ensure optimal doses of this reserve antibiotic.