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EVALUATION OF BIODISTRIBUTION OF 18F-SODIUM FLUORIDE IN MICE
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Abstract
Objective: Biological distribution of 18F-NaF in mice was evaluated at Center of Nuclear medicine and Cyclotron Department – 108 Military central hospital. Subject and method: 42 mice were divided into 07 groups, 18F-NaF was given intravenously. Bones, blood and organs samples were collected at 03, 05, 10, 20, 30, 45 and 60 minutes post-injection and percentage injected dose per gram (%ID/g) was calculated for each sample. Results: 45 and 60 minutes after IV injection, 18F-NaF radiopharmaceutical uptakes highly in the bone system of mice with %ID/g of 23.62 ± 5.58 and 23.65 ± 5.21 respectively. The corresponding ratios of bone/muscle and bone/blood were 16.84 ± 5.63 và 66.35 ± 5.59 respectively.
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Keywords
biodistribution evaluation, 18F-NaF, experimental animal
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