Article Sidebar
Views PDF: 106
EVALUATION OF BIODISTRIBUTION OF 18F-SODIUM FLUORIDE IN MICE
Main Article Content
Abstract
Objective: Biological distribution of 18F-NaF in mice was evaluated at Center of Nuclear medicine and Cyclotron Department – 108 Military central hospital. Subject and method: 42 mice were divided into 07 groups, 18F-NaF was given intravenously. Bones, blood and organs samples were collected at 03, 05, 10, 20, 30, 45 and 60 minutes post-injection and percentage injected dose per gram (%ID/g) was calculated for each sample. Results: 45 and 60 minutes after IV injection, 18F-NaF radiopharmaceutical uptakes highly in the bone system of mice with %ID/g of 23.62 ± 5.58 and 23.65 ± 5.21 respectively. The corresponding ratios of bone/muscle and bone/blood were 16.84 ± 5.63 và 66.35 ± 5.59 respectively.
Article Details
Keywords
biodistribution evaluation, 18F-NaF, experimental animal
References
2. Bastawrous S., Bhargava P., Behnia F., Djang D.S.W., Haseley D.R., «Newer PET Application with an Old Tracer: Role of 18F-NaF Skeletal PET/CT in Oncologic Practice,» RadioGraphics, vol. 34, pp. 1295-1316, 2014.
3. Even-Sapir E., Mishani E., Flusser G., Metser U., editors., «18 F-Fluoride positron emission tomography and positron emission tomography/computed tomography.,» Seminars in nuclear medicine, 2007.
4. e. a. Silveira M.B., «Synthesis, quality control and dosimetry of the radiopharmaceutical 18F-sodium fluoride produced at the Center for Development of Nuclear Technology-CDTN,» Brazilian Journal of Pharmaceutical Sciences, vol. 46, pp. 563-9., 2010.
5. Peters M.J., Wierts R., Jutten E.M., Halders S.G., Willems P.C., Brans B. , «Evaluation of a short dynamic 18F-fluoride PET/CT scanning method to assess bone metabolic activity in spinal orthopedics,» Annals of nuclear medicine, vol. 29, pp. 799-809, 2015.
6. Blake G.M., Park-Holohan S.J., Cook G.J., Fogelman I., «Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate,» Semin Nucl Med, vol. 31, p. 28 0 49, 2001.