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Date Published: 27/06/2023
Abstract Views: 220
Views PDF: 146
DOI: https://doi.org/10.51298/vmj.v527i1B.5732
Issue
Vol. 527 No. 1B (2023)
Section
Các bài báo
How to Cite
Phạm, H. K., Trần, T. C. N., Nguyễn, H. B., Trần, V. Đệ, Phạm, T. N. N., Lý, H. V. H., & Nguyễn, T. K. (2023). THE SINGLE NUCLEOTIDE POLYMORPHISM RS7671167 OF THE FAM13A GENE WITH SOME RESPIRATORY PARAMETERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Vietnam Medical Journal, 527(1B). https://doi.org/10.51298/vmj.v527i1B.5732

THE SINGLE NUCLEOTIDE POLYMORPHISM RS7671167 OF THE FAM13A GENE WITH SOME RESPIRATORY PARAMETERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Hoàng Khánh Phạm1, Thị Cẩm Nhung Trần2, Huy Bình Nguyễn3, Văn Đệ Trần1, Thị Ngọc Nga Phạm1, Huỳnh Vĩnh Hưng Lý1, Trung Kiên Nguyễn1,
1 Can Tho University of Medicine - Pharmacy
2 Hoan My hospital
3 HMU

Main Article Content

Abstract

The single nucleotide polymorphism (SNP) rs7671167 of the FAM13A gene has been implicated in several spirometry indices in patients with chronic obstructive pulmonary disease (COPD). Objectives: The study aimed to investigate the association between the SNPs rs7671167 of the FAM13A gene with some spirometry indices in 2 groups of patients, those with chronic obstructive pulmonary disease and those without this disease. Materials and methods: A case-control study with 160 patients, including 80 patients diagnosed with COPD, and 80 patients were determined not to have COPD according to GOLD 2020 criteria. Results: The study found the characteristics of SNP rs7671167, among the three genotypes, the CT genotype accounted for the highest percentage. However, there was no statistically significant difference between genotype, and allele frequency in the 2 disease groups and the control group (p>0.05). The spirometry index in the group of patients with the mean value was lower than the control group with statistical significance (p<0.001). Finding out the association of polymorphism rs7671167, the study in 2 groups of patients and the control group did not find a statistically significant relationship with the average price of spirometry indicators. Conclusion: In COPD patients in Vietnam, it is necessary to conduct a study with a larger sample size to understand the influence of the rs7671167 polymorphism on spirometry.

Article Details

Keywords

COPD, FAM13A, rs7671167, spirometry

References

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