KHẢO SÁT NỒNG ĐỘ CYSTATIN C VÀ MỨC LỌC CẦU THẬN Ở BỆNH NHÂN BETA THALASSEMIA

Abstract

Objectives: Investigation of plasma cystatin C concentration and glomerular filtration rate (GFR) in adults with beta thalassemia. Methods: A cross-sectional descriptive study of 171 subjects including 114 adults with beta thalassemia, 57 healthy subjects as controls. Plasma Cystatin C concentrations were quantified by ELISA method in all subjects. The group of patients was calculated glomerular filtration rate based on Cystatin C and plasma creatinine according to the CKD-EPI formula. Results: Plasma Cystatin C concentration in the patient group was 1.08 (0.83 - 1.5) mg/l, higher than the control group 0.76 (0.66-0.92) mg/l, p< 0.001. The rate of increase of Cystatin C concentration in the patients group was 37.7%. In the group of patients, the glomerular filtration rate (GFR) calculated according to Cystatin C was 73.13 ± 33.61 ml/min/1.73 m2, lower than calculated according to creatinine was 118.55 ± 21.37 ml/min/1.73 m2 (p< 0.001). There were 39.5% patients with GFR < 60 ml/min/1.73 m2 when calculated according to Cystatin C, while only 0.9% calculated according to creatinine. There is a relationship between the concentration of Cystatin C, GFR with urine osmolality and urinary albumin/creatinine ratio, p<0.05; however, did not find a significant relationship with the severity of the disease, p > 0.05. Conclucsion: Elevated plasma cystatin C is a common manifestation and is associated with decreased urine osmolality and urinary albumin/creatinine ratio in beta thalassemia patients