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Date Published: 27/06/2023
Abstract Views: 254
Views PDF: 220
DOI: https://doi.org/10.51298/vmj.v527i1B.5773
Issue
Vol. 527 No. 1B (2023)
Section
Các bài báo
How to Cite
Nguyễn, V. Đĩnh, Nguyễn, T. H. P., Nguyễn, H. Đông, Nguyễn, T. H. N., & Trương, C. D. (2023). CORRELATION BETWEEN INDIRECT IMMUNOFLUORESCENCE ANTI-NUCLEAR ANTIBODIES PATTERNS AND SPECIFIC NUCLEAR ANTIBODIES IN SOME COMMON SYSTEMIC AUTOIMMUNE DISEASES. Vietnam Medical Journal, 527(1B). https://doi.org/10.51298/vmj.v527i1B.5773

CORRELATION BETWEEN INDIRECT IMMUNOFLUORESCENCE ANTI-NUCLEAR ANTIBODIES PATTERNS AND SPECIFIC NUCLEAR ANTIBODIES IN SOME COMMON SYSTEMIC AUTOIMMUNE DISEASES

Văn Đĩnh Nguyễn1,2,3,, Thị Hoài Phương Nguyễn4, Huy Đông Nguyễn5, Thị Hồng Nhi Nguyễn6, Công Duẩn Trương4
1 Vinmec times City hospital
2 VinUiniversity
3 Penn State University
4 Vinmec Times City hospital
5 HUPH
6 Vinuniversity

Main Article Content

Abstract

Background: Approximately 3-5% of the population is affected including 100 types of autoimmune diseases. Antinuclear antibody (ANA) is an important biomarker for autoimmune diseases, detected by indirect immunofluorescence (IIF) method. This method has been applied wildly in several hospitals; however, there is no synchronous and complete assessment of autoantibodies. Method: This cross-sectional study was conducted on 110 medical records of individuals diagnosed with autoimmune diseases at Vinmec International Hospital from Januanry 2020 to June 2022. The IIF were performed to determine the presence of ANA. Result: The presence of ANA varies across the following diseases: undifferentiated connective tissue disease (UCTD) 82.3%, systemic sclerosis (SSc) 77.8%, systemic lupus erythematosus (SLE) 71.4%, polymyositis/dermatomyositis (PM/DM) 53.3%. The most common deposition patterns were speckled pattern and homogenous pattern. In homogenous pattern, the dsDNA, histone and nucleosomes antibodies were found frequently. Scl-70 and Ro-52 antibodies were detected in all five diseases which were studied. Conclusion: The presence of ANA detected by IIF were significantly high in UCTD, SSc, SLE, and PM/DM. The deposition patterns and the specific antibodies were different and diseases-specific.

Article Details

Keywords

ANA, lupus erythematosus, dermatomyositis/polymyositis, Sjogren Syndrome, Undifferentiated connective tissue disease

References

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