NGHIÊN CỨU TÌNH HÌNH KHÁNG KHÁNG SINH VÀ CÁC YẾU TỐ LIÊN QUAN CỦA STAPHYLOCOCCUS AUREUS ĐƯỢC PHÂN LẬP TỪ BỆNH NHÂN ĐIỀU TRỊ TẠI BỆNH VIỆN ĐA KHOA THÀNH PHỐ CẦN THƠ NĂM 2022-2023

Abstract

Background: Staphylococcus aureus is one of the leading causes of community-acquired and hospital-acquired infections, leading to serious consequences. Objectives:  Determine the rate and extent of antibiotic resistance of Staphylococcus aureus. Analysis of factors related to the antibiotic resistance rate of Staphylococcus aureus. Material and method: A cross-sectional descriptive study on 58 clinical specimens isolated from Staphylococcus aureus. Perform antibiogram test to determine the antibiotic resistance of bacterial strains to commonly used antibiotics on culture machines and automatic antibiograms. Result: The rate of Staphylococcus aureus resistant to penicillin was 95.8%, Erythromycin was 90.8% and Clindamycin was 89.5%. The rate of Staphylococcus aureus sensitive to Linezolid was 100%, Tigecycline was 100%, Nitrofurantoin was 100%, Vancomycin was 97.9%, Quinupristin/Dalopristin was 97.8%, and Rifampin was 93.7 %. The rate of MRSA was 82.1%. The rate of multi-antibiotic-resistant Staphylococcus aureus was 92.6%. MRSA had a 7.6 times higher risk of multi-antibiotic resistance than other S. aureus strains with ORs (CI95%): 7.6 (1.54-38.43) and p=0.018. The relationship between the source of bacteria and the medical history with the rate of multi-resistant S. aureus has not been recorded. Conclusion: Staphylococcus aureus was resistant to Methicillin and was highly resistant to antibiotics, but this bacterium was still highly sensitive to topical antibiotics. MRSA increases the risk of multiple antibiotic resistance.