EVALUATION OF SOME PROGNOSTIC FACTORS FOR SURVIVAL TIME AFTER CURATIVE GASTRECTOMY FOR GASTRIC ADENOCARCINOMAS AT VIET DUC UNIVERSITY HOSPITAL
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Abstract
Surgery remains the principal treatment of gastric adenocarcinomas, however, prognostic factors have been not widely studied. Objectives: To analyze some prognostic factors after curative gastrectomy in the treatment of gastric adenocarcinomas at Viet Duc University Hospital. Subject and methods: Descriptive retrospective study with longitudinal follow-up, no control on gastric adenocarcinoma cases undergoing radical surgery at Viet Duc University Hospital since January 1, 2014. until December 31, 2018. Results: 302 cases underwent radical surgery for gastric adenocarcinoma with the rate of TNM stage 0, I, II, III respectively 1.4%, 34.8%, 27.4% , 36.4%. The significant poor prognostic factors for the survival time after surgery include older age, weight loss, stenosis, gastrointestinal bleeding, anemia, elevated CEA, tumor size > 3cm, poor differentiation, neurovascular invasion, extension to the serosa (pT3-4) and lymph node metastasis. No difference in gender, laparoscopic or open surgery, D2 or D2+ lymphadenectomy. Conclusion: The 5-year survival rate could be estimated based on prognostic factors, but prospective, randomized studies are needed
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Keywords
Gastric cancer, curative surgery, prognostic factors
References
2. Trịnh Hồng Sơn. Nghiên cứu nạo vét hạch trong điều trị phẫu thuật ung thư dạ dày. Luận văn tiến sỹ y học. Đại học Y Hà Nội; 2001.
3. Song M., Kang D., Yang J. J., et al. Age and sex interactions in gastric cancer incidence and mortality trends in Korea. Gastric Cancer. Jul 2015;18(3):580-9. doi:10.1007/s10120-014-0411-x
4. Kim H. W., Kim J. H., Lim B. J., et al. Sex disparity in gastric cancer: female sex is a poor prognostic factor for advanced gastric cancer. Ann Surg Oncol. Dec 2016;23(13):4344-4351. doi:10.1245/s10434-016-5448-0
5. Huang X. Z., Yang Y. C., Chen Y., et al. Preoperative anemia or low hemoglobin predicts: poor prognosis in gastric cancer patients: A meta-analysis. Dis Markers. 2019;2019:7606128. doi:10.1155/2019/7606128
6. Deng K., Yang L., Hu B., Wu H., Zhu H., Tang C. The prognostic significance of pretreatment serum CEA levels in gastric cancer: a meta-analysis including 14651 patients. PLoS One. 2015;10(4):e0124151. doi:10.1371/journal.pone.0124151
7. Zeng F., Chen L., Liao M., et al. Laparoscopic versus open gastrectomy for gastric cancer. World J Surg Oncol. Jan 27 2020;18(1):20. doi:10.1186/s12957-020-1795-1
8. Liang Y., Cui J., Cai Y., et al. "D2 plus" lymphadenectomy is associated with improved survival in distal gastric cancer with clinical serosa invasion: a propensity score analysis. Sci Rep. Dec 16 2019;9(1):19186. doi:10.1038/s41598-019-55535-7
9. Feng F., Liu J., Wang F., et al. Prognostic value of differentiation status in gastric cancer. BMC Cancer. Sep 3 2018;18(1):865. doi:10.1186/ s12885-018-4780-0
10. Yaprak G., Tataroglu D., Dogan B., Pekyurek M. Prognostic factors for survival in patients with gastric cancer: Single-centre experience. North Clin Istanb. 2020;7(2):146-152. doi:10.14744/ nci.2019.73549