ULTRASOUND-GUIDED SYNOVIAL BIOPSY: A PRELIMINARY RESULT

Thị Hoàng Anh Châu1, Tôn Nữ Hồng Hạnh Huyền1, Trọng Bỉnh Lê2,
1 Hue University Medicine and Pharmacy hospital
2 Hue University Medicine and Pharmacy

Main Article Content

Abstract

Background: Synovial thickening is a common manifestation of various arthropathies. Apart from joint fluid aspiration, synovial membrane sampling plays a fundamental role in determining the nature of the diseases. Ultrasound-guided needle biopsy of the synovial membrane has been recognized as a safe, simple, and effective procedure. This paper aimed to assess the preliminary results of ultrasound-guided synovial biopsy at a single center. Methods: Data from 11 patients with synovial thickening from September 2019 to October 2022 at Hue University of Medicine and Pharmacy Hospital were retrospectively analyzed. Tissue sampling was collected by using an automatic biopsy gun with 16G or 18G needle. Needle size, length of core, number of passes and procedure endpoints were down to the operators. Results: The median age was 49 (range, 21-86 years), male: female ratio was 7:4. Knee joint was the most frequent site of biopsy (8/11 cases). The average number of samples was 3.63 (range, 1-5 samples), and 10-15mm in length. Technical success rate was 100%. All of the specimens were pathologically conclusive given a diagnostic yield of 100%. No intra and post procedural complications were observed. Conclusion: Ultrasound-guided synovial biopsy is a safe and effective method to determine the nature of arthropathies

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References

1. Coiffier G., Ferreyra M., Albert J.-D., Stock N., et al (2018), "Ultrasound-guided synovial biopsy improves diagnosis of septic arthritis in acute arthritis without enough analyzable synovial fluid: a retrospective analysis of 176 arthritis from a French rheumatology department", Clinical Rheumatology, 37 pp. 2241-2249.
2. Humby F., Romão V.C., Manzo A., Filer A., et al (2018), "A multicenter retrospective analysis evaluating performance of synovial biopsy techniques in patients with inflammatory arthritis: arthroscopic versus ultrasound‐guided versus blind needle biopsy", Arthritis Rheumatology, 70 (5), pp. 702-710.
3. Johnsson H., Najm A. (2021), "Synovial biopsies in clinical practice and research: current developments and perspectives", Clin Rheumatol, 40 (7), pp. 2593-2600.
4. Just S.A., Humby F., Lindegaard H., de Bellefon L.M., et al (2018), "Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe", RMD open, 4 (2), pp. e000799.
5. Kelly S., Humby F., Filer A., Ng N., et al (2015), "Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients", Annals of the rheumatic diseases, 74 (3), pp. 611-617.
6. Krenn V., Morawietz L., Burmester G.R., Kinne R., et al (2006), "Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis", Histopathology, 49 (4), pp. 358-364.
7. Madruga Dias J., Costa M., Pereira da Silva J., Viana de Queiroz M.J.I. (2014), "Septic arthritis: patients with or without isolated infectious agents have similar characteristics", Infection, 42 pp. 385-391.
8. Marin F., Lasbleiz J., Albert J., Askri A., et al (2006), "Synovial biopsy under US guidance: technical considerations and results", Journal de radiologie, 87 (5), pp. 561-565.
9. Najm A., Le Goff B., Orr C., Thurlings R., et al (2018), "Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups", Arthritis Research Therapy, 20 pp. 1-7.
10. Najm A., Orr C., Heymann M.F., Bart G., et al (2016), "Success Rate and Utility of Ultrasound-guided Synovial Biopsies in Clinical Practice", J Rheumatol, 43 (12), pp. 2113-2119.