ĐẶC ĐIỂM LÂM SÀNG VÀ TÍNH NHẠY CẢM KHÁNG SINH CỦA VI KHUẨN GÂY NHIỄM KHUẨN HUYẾT Ở NGƯỜI BỆNH ĐIỀU TRỊ TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Abstract

A cross sectional study on 300 septicemia patients treated at the Natioanl Hospital for Tropical Diseases during period 2017-2022 to describe the clinical manifestations and to evaluate antimicrobial sensitivity of bacteria causing septicemia. Of them, 71.3% had fever; 89% presented primary local infection, most of them were respiratory, gastroenterology and neurology infection; 48.3% had organ failures including 23% multiorgan failures; 15.7% had septic shock at admission. Key pathogens of septicemia included E. coli (28%), S. aureus (27.3%) and K. pneumoniae (10%). All of E. coli isolates were sensitive with amikacin, carbapenem group, piperacillin-tazobactam. Cotrimoxazole resistance was identified in 76,9% of E. coli isolates and more than 40% of E.coli were resistant to ceftriaxone, cefotaxime, ciprofloxacin and levofloxacin. Almost of K. pneumoniae isolates were sensitive with amikacin, gentamicin, carbapenem, levofloxacin, piperacillin-tazobactam; Ampicillin-sulbactam, ceftriaxone, cefotaxime, tobramycin was found to be sensitive in 80% of K. pneumoniae isolates. For S. aureus, 100% were susceptible to vancomycin, linezolide, nitrofurantoin, quininpristin and more than 90% were susceptible to cotrimoxazole, rifampicin, tigecycline, moxifloxacin; S. aureus resistant to clindamycin (67.9%), cefoxitin (60%), oxacillin (61,7%). All of S. suis were sensitive with ceftriaxone, vancomycin and linezolide; clindamycin and erythromycin resistance were found in 75% and 72,7% of S.suis isolates.