NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ MỐI LIÊN QUAN VỚI MỘT SỐ ĐẶC ĐIỂM MÔ BỆNH HỌC TRÊN BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAN GAN NHIỄM HBV ĐÃ PHẪU THUẬT TẠI BỆNH VIỆN K TÂN TRIỀU

Abstract

Objectives: To evaluate the clinical, paraclinical histopathological characteristics and the relationship of these characteristics in hepatitis B virus-related hepatocellular carcinoma patients operated at National Cancer Hospital- Tan Trieu from 2018 to 2020. Subjects and research methods: A cross-sectional descriptive study on 41 patients with hepatitis B virus-related hepatocellular carcinoma who underwent surgery. Results: The age group 50 - 69 accounts for the majority of 70.7%; the male to female ratio was 3,1/1. Clinical symptoms: right lower quadrant pain was 65.9%, fatigue was 22.0%; periodic health examination was 26.8%. AFP-negative (<20 ng/ml) rates were found in 41.5% patients. Tumor size ≥ 5cm accounted for 43.9%, group one tumor accounted for 71.6, and the majority was in the right lobe, 68.3%. Pathological characteristics: Most tumors had tumor cell differentiation grade II 63.4%, grade III 31.8%, 100% stromal invasion and 24.4% vascular invasion. AFP levels are associated with poor tumor cell differentiation and vascular invasion. Tumor size was related to poor tumor cell differentiation but not to vascular invasion in the histopathology. Conclusion: Patients with HBV-infected hepatocellular carcinoma had a large proportion of cases incidentally discovered by periodic health examination, large tumor size, and mostly moderate to poorly differentiated cell differentiation. Tumor cell differentiation is closely related to AFP levels and tumor size; Vascular invasion in histopathology was only related to AFP levels and not to tumor size.