NGHIÊN CỨU ẢNH HƯỞNG CỦA PHƯƠNG PHÁP SINH THIẾT PHÔI NANG CHƯA THOÁT MÀNG VÀ ĐANG THOÁT MÀNG ĐẾN KẾT QUẢ CHUYỂN PHÔI

Abstract

Objectives: This study aims to compare effects of non-hatching and hatching blastocyst biopsy methods on clinical outcomes. Subjects and methods: This is a retrospective cohort study on 615 single frozen-thawed euploid blastocyst transfer cycles at the center for assisted reproduction of Ha Dong 16A general hospital from March 2018 to September 2022. 247 transferred blastocysts were biopsied by the non-hatching blastocyst biopsy method and 368 transferred blastocysts were biopsied by hatching blastocyst biopsy method. Clinical pregnancy rates were calculated to evaluate effectiveness of the two methods. Results: Clinical pregnancy rates were not statistically significant different between the two biopsy groups (44.6% vs 42.6%, P = 0.626). There was no significant difference in clinical pregnancy rates between the two biopsy groups on blastocysts with similar ICM-TE morphology. Logistic regression analysis showed that the biopsy method was not a factor predicting clinical pregnancy rates (OR: 1.237, 95% CI: 0.856 - 1.790, P = 0.258). Conclusion: Non-hatching and hatching blastocyst biopsy methods are equally effective.