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Date Published: 09/09/2023
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DOI: https://doi.org/10.51298/vmj.v529i2.6492
Issue
Vol. 529 No. 2 (2023)
Section
Các bài báo
How to Cite
Bùi, T. P., Mai, T. C., Nguyễn, Đăng H., Hà, Q. A., Đoàn, P. C., Đinh, N. P., Nguyễn, T. C. L., & Mai, H. A. H. (2023). STUDY ON THE TREATMENT OF HYPERTENSION AND DIABETES OF THE RUELLIA TUBEROSA L. Vietnam Medical Journal, 529(2). https://doi.org/10.51298/vmj.v529i2.6492

STUDY ON THE TREATMENT OF HYPERTENSION AND DIABETES OF THE RUELLIA TUBEROSA L.

Thanh Phong Bùi1,, Thành Chung Mai1, Đăng Hoành Nguyễn1, Quỳnh Anh Hà1, Phước Cường Đoàn1, Ngọc Phụng Đinh1, Thị Cẩm Loan Nguyễn1, Huỳnh Anh Hào Mai1
1 Hong Bang International University

Main Article Content

Abstract

Objectives: Reducing diabetes and hypertension is usually achieVed through the inhibition of metabolic enzymes in the body such as α-glucosidase, α- amylase, dipeptidyl peptidase-4 (DPP-IV), angiotensin- conVerting enzyme (ACE). This study aimed to inVestigate the inhibitory actiVities of the aboVe enzymes of total ethanol (TP) and fraction extracts such as ethyl ether (EE), ethyl acetate (EA), n-butanol (BU), water (WA) of the Ruellia tuberosa L. ResultBased on the study, the inhibitory actiVity of α- glucosidase enzymes was strongest in EE with an IC50 value of 24.28 µg/ml, high α-amylase, DPP-IV, and ACE inhibitory actiVity. highest in EA with IC50 Values of 27.72 µg/ml, 299.85 µg/ml, and 102.93 µg/ml, respectiVely. Conclusion: The study shows that it is possible to apply explosiVe extracts to support the treatment of hypertension and diabetes.

Article Details

Keywords

Ruellia tuberosa, α-glucosidase, α- amylase, angiotensin-conVerting enzyme (ACE), dipeptidyl peptidase IV (DPP-IV).

References

1. Kitabchi, A. E., Umpierrez, G. E., Miles, J. M., & Fisher, J. N. (2009). Hyperglycemic crises in adult patients with diabetes. Diabetes care, 32(7), 1335-1343.
2. Leibovitz, E., Gottlieb, S., Goldenberg, I., Gevrielov-Yusim, N., Matetzky, S., & Gavish,



D. (2013). Sitagliptin pretreatment in diabetes patients presenting with acute coronary syndrome: results from the Acute Coronary Syndrome Israeli SurVey (ACSIS), CardioVascular Diabetology, 12-53
3. Poznyak, A. V., Sadykhov, N. K., Kartuesov,
A. G., Borisov, E. E., Melnichenko, A. A., Grechko, A. V., & Orekhov, A. N. (2022). Hypertension as a risk factor for atherosclerosis: CardioVascular risk assessment. Published online 2022 Aug 22
4. Li, K., Yao, F., Xue, Q., Fan, H., Yang, L., Li, X., ... & Liu, Y. (2018). Inhibitory effects against α–glucosidase and α–amylase of the flaVonoids- rich extract from Scutellaria baicalensis shoots and interpretation of structure-actiVity relationship of its eight flaVonoids by a refined assign-score method. Chemistry Central Journal, 12(1), 1 – 11.
5. The Han Nguyen, Thi Huyen Nguyen, Van Minh Nguyen, Thi Lan Phuong Nguyen, Thi

Van Anh Tran, Anh Duy Do, Sang Moo Kim (2019). Antidiabetic and antioxidant actiVities of red seaweed Laurencia dendroidea. Asian Pacific Journal of Tropical Biomedicine, 9(12), 501 – 509.
6. Lacroix, I. M., & Li-Chan, E. C. (2013). Inhibition of dipeptidyl peptidase (DPP)-IV and α
– glucosidase actiVities by pepsin-treated whey proteins. Journal of agricultural and food chemistry, 61(31), 7500-7506.
7. Dai-Hung Ngo, BoMi Ryu, Se-Kwon Kim (2014). ActiVe peptides from skate (Okamejei kenojei) skin gelatin diminish angiotensin-I conVerting enzyme actiVity and intracellular free radical-mediated oxidation. Food Chemistry, 143, 246-255.
8. Andi Suhendi, Agus Salim Maulana. (2021). Inhibition ActiVity of LeaVes, Flower and Root Extracts of Ruellia tuberosa L on α-glucosidase Enzymes. Journal of Nutraceuticals and Herbal Medicine, 3(2), 21-28.