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Date Published: 09/09/2023
Abstract Views: 247
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DOI: https://doi.org/10.51298/vmj.v529i2.6512
Issue
Vol. 529 No. 2 (2023)
Section
Các bài báo
How to Cite
Vũ, X. H., Lê, H. D., Hoàng, T. P., Đỗ, T. T. H., & Vũ, H. L. (2023). THE ASSOCIATION BETWEEN ANTI-U1-RNP ANTIBODY AND MULTIORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS. Vietnam Medical Journal, 529(2). https://doi.org/10.51298/vmj.v529i2.6512

THE ASSOCIATION BETWEEN ANTI-U1-RNP ANTIBODY AND MULTIORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS

Xuân Hương Vũ1,, Hữu Doanh Lê1,2, Thị Phượng Hoàng2, Thị Thu Hiền Đỗ1,2, Huy Lượng Vũ1,2
1 HMU
2 National Hospital of Dermatology and Venereology

Main Article Content

Abstract

Objective: To eValuate the association between anti U1-RNP antibody and some organ’s damage in systemic lupus erythematosus. Subjects and methods: A cross-sectional descriptiVe study was conducted on 48 systemic lupus erythematosus patients diagnosed according to the criteria of the Systemic Lupus. International Collaborating Clinics 2012 (SLICC 2012) at the National Hospital of Dermatology and Venereology from September 2021 to September 2022 and was tested to detect anti-U1- RNP antibodies in the blood using the ANA 23 profile test kit. Result: Among 48 patients participating in our study, up to 97.9% female patients. The mean age of onset was 31.6 ± 14.3 years old. The positiVe rate of anti U1-RNP antibody was 39.6% and mainly positiVe at strong leVel 3+ (47.4%). The rate of interstitial lung disease detected by high-resolution computed tomography was 39.5%, in which the anti- U1-RNP positiVe group was higher than the negatiVe group (p=0.028). The rate of increase in muscle enzymes (CK > 190 U/l) was 47.9%, in which the positiVe anti U1-RNP group (68.4%) was higher than


 


 


 


the negatiVe group (34.5%) (p=0.038). The rate of Raynaud's phenomenon in positiVe group (63.2%) was higher than the negatiVe group (17.2%) (p=0.001). Conclusion: Patients with systemic lupus erythematosus who were positiVe for anti U1-RNP had a higher risk of deVeloping lung damage, muscle damage and peripheral Vascular damage than the negatiVe group.

Article Details

Keywords

Keywords: Systemic lupus erythematosus, anti U1-RNP, lung damage, muscle damage, peripheral Vascular damage.

References

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