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GENOTYPE FREQUENCY OF AGTR1 A1166C POLYMORPHISM IN ACUTE MYOCARDIAL INFARCTION PATIENTS
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Abstract
Objects: to determine the genotype frequency of AGTR1 A1166C polymorphism in patients with acute myocardial (AMI). Subjects and methods: This was a cross-sectional and descriptive study in patients with AMI at the Department of Cardiology and Department of Interventional Cardiology, Cho Ray Hospital between January 2020 and September 2020. AGTR1 A1166C genotypes were determined by polymerase chain reaction at the Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City. Results: There were 305 patients with AMI with the mean age of 63.3 ± 11.9 years and 69.5% were men. Dyslipidemia (89.8%) and hypertension (79.0%) were the most common coronary risk factors. There were 55.0% of cases with ST-segment elevation myocardial infarction 76.7% of cases with Killip I class. The proportion of AA, AC, and CC genotypes of AGTR1 A1166C polymorphism were 90.2%, 9.5%, and 0.3%, respectively. Conclusions: CC genotype accounts for the lowest frequency in patients with AMI
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Keywords
genotype, genetic polymorphism, AGTR1 A1166C, acute myocardial infarction
References
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