MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG VÀ XÉT NGHIỆM MÁU NGOẠI VI Ở BỆNH NHÂN XƠ TỦY NGUYÊN PHÁT TẠI VIỆN HUYẾT HỌC TRUYỀN MÁU TRUNG ƯƠNG

Abstract

Objectives: To study some clinical characteristics and peripheral blood tests in primary myelofibrosis patients at the National Institute of Hematology and Blood Transfusion. Subjects and methods: We conducted a retrospective cross-sectional study on 43 patients diagnosed with primary myelofibrosis at the Department of General Blood Diseases, National Institute of Hematology and Blood Transfusion, from January 2017 to May 2022. Results: Most patients age were over 60, accounting for 69.4%. The male/female ratio was 1.1/1. Clinically, most patients had tumor syndrome, of which 79.1% had splenomegaly, 53.4% had hepatomegaly, and 9.3% had enlarged lymph nodes. Anemia symptoms were found in most patients (95.4%), accompanied by peripheral blood morphological disorders (seeing 69.8% of teardrop-shaped red blood cells; proliferation mainly in the granulocyte-intermediate stages, accounting for 51.2%; peripheral blood blast accounted for 18.6%). 60.5% of patients had mutations in the JAK2V617F gene. Conclusion: Primary myelofibrosis is mainly seen in people aged over 60 years, often with tumor syndrome and anemia in clinical practice, there are many types of peripheral blood morphological disorders in which teardrop-shaped red blood cells account for 69, 8%, 60.5% of patients have JAK2V617F mutation.