MỘT TỐ ĐẶC ĐIỂM CỦA TỦY XƯƠNG Ở BỆNH NHÂN XƠ TỦY NGUYÊN PHÁT TẠI VIỆN HUYẾT HỌC - TRUYỀN MÁU TRUNG ƯƠNG

Abstract

Objectives: To study some characteristics of bone marrow in patients with primary myelofibrosis at the National Institute of Hematology and Blood Transfusion. Subjects and methods: We conducted a retrospective cross-sectional study on 43 patients diagnosed with primary myelofibrosis at the Department of General Blood Diseases, National Institute of Hematology and Blood Transfusion, from January 2017 to May 2022. Results: Most patients with primary myelofibrosis had poor marrow density, accounting for 65.1%. Bone marrow decreased erythrocyte production (69.8%), most of which had red blood cell line morphological disorders. 53.5% of patients had a decreased leukocyte lineage. Leukocyte morphology disorder accounted for 93%, mainly disorders in the intermediate stage of granulocytes. 100% of patients had fibroblast proliferation at different levels accompanied by morphological disorders of megakaryocyte (55.8% of megakaryocytes with large size, large shaggy nuclei with reduced abs; bare megakaryocytes nuclei accounted for 9.3%), megakaryocytes standing in groups accounted for 69.8%.