ĐÁNH GIÁ TÁC DỤNG KHÔNG MONG MUỐN CỦA BỆNH NHÂN UNG THƯ VÚ TÁI PHÁT DI CĂN KHI ĐIỀU TRỊ BẰNG FULVESTRANT TẠI BỆNH VIỆN K

Abstract

Objective: To evaluate the results of initial treatment of FLOT regimen on advanced gastric cancer at K Hospital. Subjects and methods: The study carried out descriptive analysis, longitudinal follow-up analysis of 32 cases of advanced gastric adenocarcinoma at K hospital. The patients received chemotherapy with FLOT regimen including Docetaxel 50. mg/m2, IV infusion on day 1. Oxaliplatin 85 mg/m2, IV infusion on day 1. Leucovorin 200 mg/m2, IV infusion on day 1. Fluorouracil 2600 mg/m2, IV infusion on day 1. Cycle 14 days. Treatment 4 cycles before surgery, 4 cycles after surgery. For patients with late gastric stage treated for 8 cycles, evaluated after 4 cycles. The patients were monitored and evaluated for tolerability and response to treatment. Results: 32 patients in which the patients in the study were all at stage T4, in which the rate of T4b was higher with 53.1%. The patients participating in the study were mainly in stage IV (81.2%). In the group of patients with metastases, the most common site of metastasis was peritoneal metastasis. After 4 cycles, the rate of patients with tumor response was 71%, lymph node response was 68.7%, and response at metastatic site was 70%. Among 6 patients receiving neoadjuvant therapy, 4 patients evaluated for response (complete and partial) were transferred to surgery to remove the total gastric, lymph node dissection. 18 patients had a partial response, followed by treatment, accounting for 56.3%. In 13 patients who could complete 8 cycles of FLOT, the partial response rate was up to 76.9%.