NGHIÊN CỨU TÁC DỤNG KHÁNG VIÊM CỦA CAO CHUẨN HOÁ KIỂM SOÁT HÀM LƯỢNG CÁC CURCUMINOID TỪ THÂN RỄ NGHỆ VÀNG (RHIZOMA CURCUMA LONGA L.) TRÊN CHUỘT NHẮT TRẮNG

Abstract

Background: Rhizoma Curcumae longae is a very common medicinal plant grown in Southeast Asia with many useful uses such as antibacterial, cancer treatment, anti-inflammatory, stomach ulcers [1]. There have been many pharmacological studies on turmeric but currently there are no  pharmacological study of curcuminoids standardized extract. Therefore, there is a need to investigate the in vivo anti-inflammatory effect, which is the premise for the creation of standardized extracts that control the curcuminoid content of turmeric to improve the patient's inflammation. Objective: To evaluate the anti-inflammatory effects of standardized extracts of curcumine I, II, III from turmeric rhizomes in Swiss albino rats. Materials and methods: Highly standardized turmeric with controlled curcuminoid content was determined by liquid chromatography coupled with photodiode array detector (HPLC/PDA). Using carrageenan mouse paw inflammation model and measuring rat paw edema to evaluate anti-inflammatory effect. Results: High standardized turmeric at both 0,4 g/kg and 0,8 g/kg doses demonstrated anti-inflammatory effects in a rat foot edema model caused by acute carrageenan. At a dose of 0,8 g/kg, they both reduced the level of inflammation of the rat's feet to a statistical significance compared to the physiological control group and exhibited the same anti-inflammatory effect as diclofenac. Conclusion: High standardization of turmeric 0,8 g/kg gives good anti-inflammatory effect on white mice equivalent to diclofenac 0,05g/kg.