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Date Published: 06/10/2023
Abstract Views: 225
Views pdf: 131
DOI: https://doi.org/10.51298/vmj.v530i2.6830
Issue
Vol. 530 No. 2 (2023)
Section
Các bài báo
How to Cite
Phan, T. N. V., & Khưu, M. L. (2023). EVALUATING THE PRE-EMPTIVE ANALGESIC EFFICACY OF GABAPENTIN IN PATIENTS UNDERGOING SPINAL FUSION SURGERY . Vietnam Medical Journal, 530(2). https://doi.org/10.51298/vmj.v530i2.6830

EVALUATING THE PRE-EMPTIVE ANALGESIC EFFICACY OF GABAPENTIN IN PATIENTS UNDERGOING SPINAL FUSION SURGERY

Tôn Ngọc Vũ Phan1,, Minh Lợi Khưu2
1 Ho Chi Minh City University of Medicine and Pharmacy Hospital
2 Trieu An Hospital

Main Article Content

Abstract

Background: Multimodal analgesia has been shown to provide many benefits such as improving the effectiveness of pain relief, reducing opioid side effects and shortening hospital stay, especially for surgery types that cause as much pain as spinal fusion surgery. Gapapentin plays a role in reducing allodynia and hyperalgesia, thereby contributing to postoperative pain relief. Objectives: To assess the analgesic effectiveness and adverse effects of gabapentin after spinal fusion surgery. Subjects and Methods: In a randomized, placebo-controlled study was conducted on 60 patients undergoing spinal fusion sugery from 02/2021-04/2022 and randomly assigned to two groups. Study group received a single dose of oral gabapentin (600mg) and control group received placebo. The primary endpoint was total dose of morphine consumed in the 24 hours after surgery. Pain scores on the VAS scales at rest and during movement, as well as side effects were also recorded. Results: There was a significant difference in the total dose of morphine consumed in the first 24 hours after surgery between the two groups, the gabapentin group was 13.9 ± 4.54 mg and the control group was 17.1 ± 4,98 mg; p = 0.013. The diffenrence of VAS pain scores at rest and movement at 1, 3, 6, 12 and 24 hours after surgery was not statistically significant (p > 0.05). The gabapentin group had a significantly lower rate of nausea and vomiting (10%) than the control group (36.7%; p = 0.032). Other side effects such as dizziness, respiratory depression, over-sedation and pruritus were similar in both groups. Conclusion: Gabapentin is effective in pain relief in patients undergoing spinal fusion surgery. In addition, gabapentin helps reduce the rate of nausea and vomiting after surgery.

Article Details

Keywords

Gapapentin, spinal fusion surgery, multimodal analgesia.

References

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