TỈ LỆ NHIỄM VÀ CÁC YẾU TỐ LIÊN QUAN ĐẾN NHIỄM TOXOCARA CANIS TRÊN BỆNH NHÂN MÀY ĐAY MẠN TÍNH ĐẾN KHÁM TẠI BỆNH VIỆN ĐẠI HỌC Y DƯỢC THÀNH PHỐ HỒ CHÍ MINH NĂM 2022 - 2023

Abstract

Objectives: To determine the prevalence of positive serological response to Toxocara canis (T.canis) among chronic spontaneous urticaria (CSU) patients by using ELISA. Materials and methods: A cross – sectional study was conducted in 107 patients with chronic spontaneous urticarial at the University Medical Center Ho Chi Minh City from 11/2022 to 5/2023. Results: The prevalence of CSU patients with positive T.canis serological response was 23,4%. Mean age of the study subjects was 36.76 ± 11.39 years. The mean duration of urticaria in the positive and negative T.canis serological response groups was 10.72 ± 12.8 months and 12.67 ± 19.57 months, respectively (p = 0,75). The clinical characteristics of CSU patient with positive T.canis serological response were fatigue, weight loss, abdominal pain and headache. The mean blood eosinophil counts and the mean serum total IgE levels were not significantly different between T.canis serological positive (0,21 ± 0,22.10⁹/L and 595,4 ± 958,6 IU/ml) and negavive groups (0,22 ± 0,18.10⁹/L and 261,8 ± 436,9 IU/ml) (p > 0.05). The prevalence of several factors between positive and negative T.canis groups were having dogs at home 60% and 32.9%, soil contacting 40% and 19.5%, periodic deworming 12% and 40.2%, and eating raw vegetables 100% and 78% (p < 0.05). Conclusion: The prevalence of positive T.canis serological response among patient with CSU was 23.4%. Clinical characteristics were not significantly different between positive and negative T.canis serological reponse groups.