KHẢO SÁT CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN THÁI ĐỘ VÀ RÀO CẢN KHI THAM GIA NGHIÊN CỨU THỬ NGHIỆM LÂM SÀNG CỦA NGƯỜI DÂN TẠI THÀNH PHỐ HỒ CHÍ MINH

Abstract

Background: Clinical trials (CTs) are conducted on humans to evaluate the safety, clinical efficacy, pharmacological effects, pharmacodynamics, and pharmacokinetics of drugs, vaccines, and medical biological products. Objective: This study was aimed at assessing attitudes toward and barriers to participation in CTs among the population of Ho Chi Minh City (HCMc). Methods: A descriptive cross-sectional study was conducted in February 2022 to distribute a questionnaire developed on the basis of previous research. Items were scored on a five-point Likert scale ranging from 1 (“strongly disagree”) to 5 (“strongly agree”). The collected data were described and analyzed using the Statistical Package for the Social Sciences (version 22.0). Results: There were 581 valid participants, whose overall scores on attitudes and barriers were 72.8 ± 13.9 and 58.6 ± 14.6, respectively. The respondents showed the highest attitudinal score with respect to the item “participation in clinical trials helps develop new medication” (Percentage Mean Score - PMS = 79.2) and the highest barrier-related score with regard to the item “I am afraid of the risks (safety) of participation in clinical trials” (PMS = 73.0). Health status, chronic disease status, and doctor recommendation to join CTs influenced the participants’ attitude-related scores, whereas gender, age, education level, marital status, children, and doctor recommendation to join CTs affected their barrier-related scores. Conclusion: HCMc citizens have positive attitudes toward CTs but encounter above-average barriers to such participation. Assessing public attitudes toward and barriers to participating in CTs helps acquire the data and information necessary to design suitable CT models for the Vietnamese population.