Article Sidebar

PDF
Date Published: 15/11/2023
Abstract Views: 259
Views PDF: 162
DOI: https://doi.org/10.51298/vmj.v531i2.7198
Issue
Vol. 531 No. 2 (2023)
Section
Các bài báo
How to Cite
Đỗ , T. L. Q. ., Hoàng , T. T. ., Lê, V. N. ., & Hồ , H. T. (2023). ASSOCIATION BETWEEN SERUM HBV pgRNA AND HBV DNA IN TREATMENT-NAIVE CHRONIC HEPATITIS B AND LIVER CIRHOSSIS RELATED HBV. Vietnam Medical Journal, 531(2). https://doi.org/10.51298/vmj.v531i2.7198

ASSOCIATION BETWEEN SERUM HBV pgRNA AND HBV DNA IN TREATMENT-NAIVE CHRONIC HEPATITIS B AND LIVER CIRHOSSIS RELATED HBV

Thị Lệ Quyên Đỗ 1,, Tiến Tuyên Hoàng 1, Văn Nam Lê1, Hữu Thọ Hồ 2
1 103 Military Hospital, Vietnam Military Medical Academy
2 Vietnam Military Medical Academy

Main Article Content

Abstract

Objective: To assess the association between serum HBV pgRNA và HBV DNA in patients with Chronic Hepatitis B and HBV-related liver cirrhosis. Subjects and Methods: A total of 135 treatment-naïve patients with chronic HBV infection were enrolled at the Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, from 2017 to 2020. Based on the clinical, biochemical, serological, and histological data, as well as HBV DNA levels, patients were classified into two groups: Chronic Hepatitis B (CHB, n=105) and HBV-related liver cirrhosis (LC, n=30). The parameters and distribution patterns of serum HBV pgRNA were evaluated in relation to viral replication status. The relationships between serum HBV pgRNA and HBV DNA were analyzed. Result: HBV pgRNA and HBV DNA had a positive moderate correlation CHB group (r = 0.39, p < 0.01), there was no correlation between HBV pgRNA and HBV DNA in LC group. In the CHB group with ALT ≥ 200 U/L and the cirrhosis group with negative HBeAg recorded a positive, fairly strong correlation between HBV pgRNA and HBV DNA (r=0.5 and 0.58, p<0.05). Conclusion: HBV pgRNA has a linear positive correlation with HBV DNA, which makes it a useful marker for in combination with HBV DNA in the monitoring and management of patients with HBV infection and cirrhosis.

Article Details

Keywords

Hepatitis B virus (HBV), Pregenomic RNA (pgRNA), HBV DNA, CHB, LC.

References

1. World Health Organization, Hepatitis B. 2023.
2. Barnady Flower and e.a. Duc Du Hong, Seroprevalence of Hepatitis B, C and D in Vietnam: A systematic review and meta-analysis. Lancet Reg Health West Pac, 2022. 24: p. 100468.
3. Runer Kumar, et al., Clinical relevance of the study of hepatitis B virus covalently closed circular DNA. 2016. 36(S1): p. 72-77.
4. Katja Giersch, L.A., Tassilo Volz, Maura Dandri, Marc Lütgehetmann, Serum HBV pgRNA as a clinical marker for cccDNA activity Katja Giersch, Lena Allweiss, Tassilo Volz, Maura Dandri, Marc Lütgehetmann. Journal of Hepatology, 2016. S0168-8278(16)30641-9.
5. Bộ Y tế, Hướng dẫn chẩn đoán và điều trị bệnh viêm gan vi rút B. Quyết định số 5448/QĐ - BYT 30/12/2014, 2015.
6. Florian Van Bommel et al, Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors. Hepatology, 2015. 61(1): p. 66-76.
7. Yao Xie, et al., HBV DNA level and antigen concentration in evaluating liver damage of patients with chronic hepatitis B. Hepatobiliary Pancreat Dis Int, 2003. 2(3): p. 418-422.
8. Florian van Bömmel1, A.v.B., A. Krauel3, H. He4, C. Wat4, Serum HBV PGRNA is an Early Predictor of HBeAg Seroconversion in Patients with Chronic Hepatitis B (CHB) Treated With Peginterferon Alfa-2a (40KD), EASL 2015.
9. M.J. van Campenhout, et al., Serum hepatitis B virus RNA level is associated with hepatitis B virus genotype and BCP mutations in untreated patients with HBeAg positive chronic hepatitis B. Journal of Hepatology, 2017. 66: p. S253-S254.