ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ UNG THƯ VÚ CÓ DI CĂN NÃO

Abstract

Purpose: To evaluate clinical, subclinical characteristic and the survival outcome of brain metastatic breast cancer. Methods: A retrspective study on 73 patients with brain metastatic breast cancer in theNational cancer hospital from 2017 to 2022. Results: The mean age of breast cancer patients with brain metastases was 52 years, brain metastases were more common in patients with a later stage of the disease when most of them had metastases extracerebral organs such as lung, bone, liver. Patients was also often diagnosed with breast cancer with high histological grade, most the histology is invasive ductal carcinoma and the most subtypes are Her2(+) and tripple negative. The rate of control in the brain in patiens treating by Gamma knife at 3 months was 91.7%, and at 6 months was 75%. Overall survival time was 30.5 ± 3.6 months in the group of patients who are eligible for Gamma Knife radiosurgery, while those with multifocal brain metastases had modest overal survival time is 6.2 ± 1 months. Conclusion: Brain metastatic breast cancer remains a treatment challenge. Patients with limited metastatic lesions treated by Gamma Knife radiosurgery had significantly higher overal survival compared with patients with multifocal brain metastases treated by whole brain radiation therapy.