ĐÁNH GIÁ ẢNH HƯỞNG LÊN HUYẾT ĐỘNG CỦA NORADRENALIN KẾT HỢP VASOPRESSIN Ở BỆNH NHÂN SỐC NHIỄM KHUẨN

Abstract

Objective: This study aimed to evaluate the hemodynamic effectiveness of combining Noradrenaline (NE) with Vasopressin (AVP) or Terlipressin (TP) in septic shock patients. Methods: A single-center, randomized intervention study was conducted on 29 septic shock patients. Patients receiving NE at a dose of ≥0.1 mcg/kg/minute for one continuous hour were either administered AVP (0.03 U/minute) or TP (40 mcg/hour) continuously. NE dosage was titrated to achieve the target blood pressure. Hemodynamic parameters were compared before and after the administration of the combination therapy (AVP/TP), and adverse effects were recorded. Results: After combining NE with AVP/TP, there was an improvement in hemodynamic parameters, including an increase in mean blood pressure, a decrease in heart rate, an increase in systemic vascular resistance index (SVRI), and a reduced NE dose required. The rate of serious adverse effects after combining AVP/TP was 6.8%, which was not significantly different from the rate of adverse effects observed in previous studies using NE alone (p=0.79). Conclusion: Early combination therapy of NE with AVP/TP improves hemodynamics by increasing SVRI, elevating mean arterial pressure, and reducing heart rate, with no significant difference in the rate of adverse events compared to NE monotherapy as observed in previous studies.