NGHIÊN CỨU TÌNH TRẠNG TỔN THƯƠNG GAN DO THUỐC TẠI TRUNG TÂM TIÊU HÓA GAN MẬT - BỆNH VIỆN BẠCH MAI

Abstract

Objectives: Description of clinical and subclinical characteristics and investigation of drugs causing liver damage in patients with drug-induced liver injury at Gastroenterology-Hepatobiliary Center, Bach Mai Hospital. Subjects and methods: A cross-sectional descriptive study on 50 patients diagnosed with drug- induced liver injury inpatient treatment at Gastroenterology and Hepatobiliary Center - Bach Mai Hospital from August 2022 to the end of July 2023. Result: Male/Female ratio: 44/56 (%), Mean age:56.1±13.1. Reason for admission: jaundice was the most common (60%), followed by fatigue (22%). Common clinical symptoms are: fatigue (96%), jaundice (78%). The mean AST/ALT: 624 ± 619/870 ± 830 (UI/ml), the mean Total Bilirubin: 196.6 ± 146.9 µmol/l, the patients with PT < 70%: 30%, patients with INR ≥ 1.5: 20%. Types of liver injury: Necrotic/ cholestatic/ mixed form is: 70/16/14 (%). Distribution of severity: mild/moderate/severe/acute liver failure/critical is: 18/8/60/12/2 (%). Cause of DILI: traditional medicine/western medicine/functional food is: 50/44/6(%). Western medicines cause DILI: Paracetamol/ Long-acting anti-inflammatory or immunomodulatory / anti-tuberculosis/ dyslipidemia/ antifungal/ biological preparations/ Amoxicillin- clavunic, combined with Paracetamol, Esomeprazole/ NSAID+Paracetamol/Thyrozole are: 4/4/3/3/2/2/2/1/1