NGHIÊN CỨU ĐỘC TÍNH CẤP, ĐỘC TÍNH BÁN TRƯỜNG DIỄN CỦA VIÊN NANG NHẤT GAN LINH TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objectives: Determination of the acute and sub- chronic toxicity of Nhat gan linh. Methods: Determination of LD50 of Nhat gan linh by oral on white mice (Swiss) administration according to Litchfield - Wilcoxon method and WHO guidelines. Determination of the sub-chronic toxicity of Nhat gan linh according WHO and Ministry of Health guidelines on rabit (New Zealand White): 30 rabit were divided equally into 3 groups, the first group experienced the oral dose of 300mg/kg/24h (equivalent to human dose), group 2 experienced the oral dose of 900mg/kg/24h for 12 consecutive weeks and the control group. Results: The dose of LD50 has not been determined because the mice did not die. Rabit with the Nhat gan linh oral dose of 300mg/kg/24h and 900mg/kg/24h did not experience significant change in general condition; hematological and biochemical indexes (p>0,05). Morphology and histopathology of the livers and kidneys remained unchanged. Conclusions: Nhat gan linh does not cause acute in white mice and sub-chronic toxicity in experimented animal.