ĐẶC ĐIỂM LÂM SÀNG VÀ CÁC TỰ KHÁNG THỂ CỦA VIÊM THỊ THẦN KINH

Abstract

Objectives: To investigate the clinical features and antibody profiles in adults with optic neuritis. Method: In this cross-sectional study, 62 patients diagnosed with optic neuritis according to the standards of the Ministry of Health, 2015 at the Neurological Center - Bach Mai Hospital and the Department of General Internal Medicine - Hanoi Medical University Hospital from July, 2022 to August, 2023. Results: The mean age of the study population was 45,45 ± 15,28. The male to female ratio was 0,55. 100% of patients who have symptoms of a decrease or loss of vision. 73,1% patients at the time of admission had visual acuity < 5/10. Papillitis was the most prevalent fundus lesions at admission, at 57.6%. Prolongation of P100 latency was observed in 69.2% in the affected eye. Positivity rate of AQP4-IgG was the highest, at 22.6%, followed by MOG-IgG and Oligoclonal bands at 11.3% and 8.1%, respectively. Patients with OCBs (+) had a higher rate of white matter lesions than those with OCBs (-) (23.8% vs 0%). Conclusion: Optic neuritis with severe visual impairment at onset. The rate of OCBs (+) was higher in the group with white matter lesions on MRI brain – orbit compared with the group without white matter lesions