ĐÁNH GIÁ NỒNG ĐỘ HORMON TUYẾN CẬN GIÁP VÀ CÁC YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN GHÉP THẬN TẠI BỆNH VIỆN NHÂN DÂN 115

Abstract

Background: Secondary hyperparathyroidism is a common complication observed in chronic kidney disease (CKD) patients that persists even after kidney transplantation. This condition can lead to mineral bone disease, impact kidney graft function, and is linked to cardiovascular risks post-transplantation. Objectives: This study aimed to investigate plasma parathyroid hormone (PTH) concentrations in kidney transplant recipients and examine their relationship with recipient factors. Subjects and Methods: This cross-sectional study involved kidney transplant recipients observed at the People's Hospital 115 from August 2020 to August 2021. Data on plasma parathyroid hormone levels and patient characteristics were gathered during this period. Results: Among the 234 studied patients, mean age were 49.51 ± 11.68 years, 172 (73.5%) were male. The mean estimated glomerular filtration rate (eGFR) was 70.05 ± 16.29 ml/min/1,73 m². CKD staging showed 10.3% at stage 1T, 67.1% at stage 2T, 21.4% at stage 3T, and 3.1% at stage 4T; no patients were at stage 5T. The mean dialysis duration before transplantation was 28.2 ± 26.4 months (range: 3 to 150 months). The mean time since transplantation was 54,6 ± 42,8 months (range: 3 - 216 months). The mean PTH level was 129.72 ± 84.52 pg/ml, with 82.1% of patients having hyperparathyroidism, 17.9% with normal PTH levels, and none having hypo-concentration of PTH. Within the group of patients with elevated PTH, 63% had mild elevation, 27.6% had moderate elevation, and 9.4% had severe elevation. No significant correlations were observed between plasma PTH concentration and age, sex, time since transplant, dialysis duration, or eGFR. Conclusion: 82.1% of post-transplant patients had elevated plasma PTH levels, with no correlations found between PTH concentration and age, gender, transplant or dialysis duration, or eGFR.