NGHIÊN CỨU BIẾN ĐỔI NỒNG ĐỘ VÀ GIÁ TRỊ TIÊN LƯỢNG CỦA NGAL HUYẾT TƯƠNG Ở BỆNH NHÂN VIÊM TỤY CẤP CÓ TỔN THƯƠNG THẬN CẤP

Abstract

Subjects and methods: Prospective descriptive study, comparing 3 groups of subjects: 51 patients acute pancreatitis associated with acute kidney injury, 168 patients acute pancreatitis without acute kidney injury and 35 healthy people as healthy controls at Bach Mai Hospital, from October 2021 to June 2023. Result: - Among 51 patients acute pancreatitis associated with acute kidney injury, 47.1% were stage 1; 33.3% stage 2; 19.6% stage 3. - Plasma NGAL concentration of the acute pancreatitis group with acute kidney injury (570.9 ng/mL) was higher than the group without acute kidney injury (400.6ng/mL) and both were greater than the healthy control group (234.3ng/mL), the difference is statistically significant. - The median value of plasma NGAL gradually increases with the stages of acute kidney injury, the difference is statistically significant. - The cutoff point of plasma NGAL 504.29 ng/mL gave a sensitivity of 60.8% and a specificity of 68.4% (AUC = 0.684; p < 0.001) in predicting acute kidney injury in patients with pancreatitis. - The cutoff point of plasma NGAL is 486.03 ng/mL with a sensitivity of 66.1% and a specificity of 66.4% (AUC=0.651; p<0.005) in predicting the severity of acute pancreatitis. Conclusion: Plasma NGAL levels are elevated and have prognostic value in patients with acute pancreatitis and acute kidney injury. Plasma NGAL biomarkers should be used to predict acute kidney injury in patients with acute pancreatitis.