MỐI LIÊN QUAN GIỮA ĐẶC ĐIỂM HÌNH ẢNH CẮT LỚP VI TÍNH VÀ TÌNH TRẠNG ĐỘT BIẾN GEN EGFR Ở BỆNH NHÂN UNG THƯ PHỔI BIỂU MÔ TUYẾN

Abstract

Purpose: The aim of this study was to investigate the relationship between Computed tomography (CT) features and EGFR mutation in patients with adenocarcinoma of the lung. Material and Methods: One hundred and thirty eight lung adenocarcinoma patients who underwent surgery or core biopsy were retrospectively included in this study. Examination of EGFR gene mutation was performed on all tumor samples. The 138 recruited lung adenocarcinoma patients were divided into groups according to EGFR mutation status: patients with mutations in exons 18–21 (effective mutated, n = 68) and non‐mutated (n = 70). The clinical characteristics and lung CT imaging features of the two groups were recorded and compared. Univariate and logistic regression analysis were performed to identify the independent risk factors relevant to effective EGFR gene mutation. Results: The independent risk factors relevant to effective EGFR mutation were evaluated by logistic regression test. The results indicated that lung CT features of semi‐solid lesion density (OR 3.282), Air bronchogram (OR 5.041), Halo sign (OR 3.073) and pleural indentation sign (OR 3.357) were independent risk factors relevant to EGFR mutation. Conclusion: The use of CT features for patients may allow analyses of tumours and more accurately predict patient populations who will benefit from therapies targeting treatment.