KẾT QUẢ PHẪU THUẬT NỘI SOI NGỰC BỤNG CẮT THỰC QUẢN DO UNG THƯ BIỂU MÔ CÓ HÓA XẠ TRỊ TIỀN PHẪU TẠI BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC

Abstract

Objectives: Comment on the response to preoperative chemoradiotherapy in a group of patients undergoing minimally invasive surgery for esophageal cancer at Viet Duc Friendship Hospital from 2017 to 2022 and evaluate the surgical outcomes in this patient group. Subject and methods: A descriptive retrospective study was conducted on 40 patients with esophageal cancer located in the middle third to lower third of the esophagus who underwent preoperative chemoradiotherapy followed by minimally invasive surgery for esophageal cancer. Results: The rates of complete response and partial response were 37.5% and 62.5% respectively. The response rates in patients with different histological subtypes were statistically significant with a p-value < 0.05. The duration of the interval between the end of radiotherapy and surgery had a significant impact on the response rate, with a statistically significant p-value of <0.05. The average duration of surgery was 310.0 ± 34.5 minutes, and the average blood loss was 102.75 ± 58.6 ml. The average number of lymph nodes harvested during the entire surgical procedure was 19.38 ± 11.31, with a minimum of 5 nodes and a maximum of 69 nodes. The R0 resection rate was 100%. The postoperative complication rate was 32.5%, with respiratory complications accounting for 22.5%. The average additional survival time was 48.4 ± 4.8 months. The estimated average survival rates at 1 year, 3 years, and 5 years were 76.9%, 61.9%, and 51.1%, respectively. The extent of invasion, lymph node metastasis, histological differentiation, and especially the response rate after radiotherapy significantly influenced the additional survival time with a p-value of <0.05.