TỈ LỆ GÃY XƯƠNG ĐỐT SỐNG Ở PHỤ NỮ CAO TUỔI BỊ LOÃNG XƯƠNG VÀ MỘT SỐ YẾU TỐ LIÊN QUAN

Abstract

Objectives: To investigate the prevalence of vertebral compression fracture and related factors in older women with osteoporosis. Methods: This cross-sectional study was conducted on 279 older women with osteoporosis at the Rheumatology and Neurosurgery department, and Rheumatology clinic, University Medical Center, from August 2022 to May 2023. Clinical symptoms, thoracic–lumbar spine radiologic results, bone mineral density and related factors were collected. Results: 102/279 (36,6%) older women have at least one vertebral fracture and more than 50% of participants present as symptomatic. Age, marital status, physical activity, hypertension, diabetes mellitus, osteoarthritis, ischemic heart disease, frailty, falls, and T-score at femoral neck, total hip and lumbar spine are associated with vertebral compression fracture. When using multivariate logistic regression, only physical activity (OR: 0,44; 95% CI: 0,20 – 0,94; p = 0,038), osteoarthritis (OR: 0,24; 95% CI: 0,12 – 0,48; p <0,001), frailty (OR: 7,41; 95% CI: 3,45 – 16,73; p <0,001); falls (OR: 3,86; 95% CI: 1,68 – 9,32; p = 0,002), T-score at femoral neck (OR: 0,63; 95% CI: 0,41 – 0,92; p = 0,002)  are associated with vertebral fracture. Conclusion: The prevalence of vertebral compression fracture is quite high among elderly women with osteoporosis, highlighting a disease burden in this population. Physical activity, osteoarthritis, higher T-score at femoral neck are protective factors while frailty and falls are risk factors of vertebral fracture.