LIÊN QUAN GIỮA ĐỘ NGƯNG TẬP TIỂU CẦU VỚI MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG Ở BỆNH NHÂN BỆNH MẠCH VÀNH ĐƯỢC ĐIỀU TRỊ BẰNG ASPIRIN VÀ/HOẶC CLOPIDOGREL

Abstract

Aim: Evaluate the relationship between platelet aggregation and some clinical and paraclinical characteristics in coronary artery disease patients treated with Aspirin and/or Clopidgrel. Objects and method: Prospective, cross-sectional study on patients with coronary artery disease aged 18 years or older who were monitored for treatment at the Department of Cardiovascular Intervention - 175 Military Hospital during the period from November 2021 to September December 2022. Results: In 201 patients studied, men accounted for 74.63% and women accounted for 25.37% with an average age of 62.83 ± 11.02. There was no statistically significant difference in platelet aggregation and Clopidogrel/Aspirin resistance according to age and gender. The differences in platelet aggregation and resistance to Aspirin and/or Clopidogrel between clinical types are not statistically significant. The anemic patient group had significantly higher platelet aggregation and Clopidogrel resistance rates than the non-anemic patient group (p<0.05). The group of patients resistant to Clopidogrel had a significantly higher average platelet count than the group of non-resistant patients (p<0.05). The group of patients using PPIs had significantly higher platelet aggregation and drug resistance rates than the group of patients not using PPIs (p<0.05). Conclusion: The group of patients with anemia and using PPIs had higher platelet aggregation and drug resistance than the group of patients without anemia and not using PPIs (p<0.05). The group of patients resistant to Clopidogrel had a significantly higher average platelet count than the group of patients without resistance (p<0.05).