BIỂU HIỆN PDL-1 TRONG UNG THƯ TẾ BÀO GAI HỐC MIỆNG

Abstract

Objectives: The aim of this study was to characterise the PD-L1 immunohistochemical expression in oral cavity squamous cell carcinoma (OSCC) and its association with clinicopathological factors and radiotherapy response after 5-year follow-up. Methods: A cohort study was conducted on 157 OSCC patients at Ho Chi Minh City Oncology Hospital. Clinical characteristics and treatment history were recorded from patient medical records. Paraffin-embedded specimens were sectioned at a thickness of 4 μm. We assessed the histopathologic grade of each case according to the Anneroth classification. Immunohistochemical staining of archived tissue samples was performed using anti-PD-L1 antibodies. The progression-free survival (PFS) was monitored for 5 years. PFS less than 2 years in patients receiving a radiation dose ≥ 50 Gy was considered radioresistance, while PFS ≥ 2 years was defined as a radiosensitivity. Results: PD-L1 expression was observed in 60,5% of cases and was found to be associated with alcohol consumption habits (p = 0,024), lower lympho-plasmacytic infiltration (p=0,049), but not with other clinical or pathological characteristics. Positivity for PD-L1 in primary tumors was associated with a 1,5-fold increased risk of radioresistance (95% CI = 1,17-1,86) compared to PD-L1 negative staining (p < 0,001). Conclusion: Positive PD-L1 expression may be a predictive factor of radioresistance in OSCC.