NỒNG ĐỘ ALPHA-1 ANTITRYPSIN HUYẾT TƯƠNG Ở BỆNH NHÂN BỆNH PHỔI TẮC NGHẼN MẠN TÍNH TẠI BỆNH VIỆN NGUYỄN TRI PHƯƠNG

Abstract

Background: Quantification of αlpha-1 antitrypsin (AAT) for early detection of chronic obstructive pulmonary disease (COPD) with reduced AAT. The plasma AAT level in Vietnamese patients has not been clarified. Objective: Characterization of plasma AAT concentration values in COPD patients at Nguyen Tri Phuong Hospital. Subjects and methods: a case series study, prospective sample collection, conveniently, on 70 patients diagnosed with COPD(GOLD 2022 criteria), at Nguyen Tri Phuong hospital, from 04/2022 to 08/2022. Plasma AAT levels were performed at the Laboratory Department of the hospital. Data is analyzed by using SPSS 20.0 software. Using the MannWhitney and KruskalWallis tests with a significant difference of p<0.05. Results: The 70 participants were most concentrated in the age group of 61-70 and mainly men. 95.7% had a diagnosis of COPD aged 40 years or older, 81.4% had active smoking, 26.7% had a history of asthma, 92.9% had no family history of COPD diagnosis, 91.5% had an FEV1/FVC < 0.7, and 40.4% had a 0.5 ≤ FEV1 < 0.8. The median plasma ATT level was 142.3 (128.3 – 156) mg/dL. There was no statistically significant difference in plasma AAT levels by age, sex, asthma history, family history, respiratory outcomes. There was an increase in plasma AAT levels in smokers compared with nonsmokers (p=0.017). Conclusion: plasma AAT levels in study subjects have been determined. Plasma AAT levels were initially determined to be significantly higher in the smoker group than in the non-smoking group.