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STUDY ON THE ANALGESIC EFFECT OF “TD.NQ” CAPSULES ON EXPERIMENTAL ANIMAL
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Abstract
Objective: Study the analgesic effect of "TD.NQ" capsules on a mouse model of knee osteoarthritis. Subjects and methods: Wistar white rats (provided by the Vietnam Military Medical Academy). Both breeds, healthy, weight 180 ± 40 g. Methods: study the analgesic effect of TD.NQ capsules on rats with MIA-induced knee osteoarthritis, using P.A.M pressure model and gauge pain threshold method. Results: TD.NQ dose of 4,266 g/kg has a clear analgesic effect on the P.A.M pressure model, an unclear analgesic effect on the gauge pain threshold method. TD.NQ dose of 12,798 g/kg has an analgesic effect on the P.A.M pressure model, the analgesic effect is unknown on the gauge pain threshold method. Conclusion: TD.NQ capsules with both doses of 4,266 g/kg and 12,798 g/kg have a clear pain-relieving effect on the P.A.M pressure model, but the effect is unclear on the gauge pain threshold method. The dose of 12,798 g/kg tends to have better effects but there is no statistically significant difference.
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Keywords
analgesia, TD.NQ, traditional medicine.
References
2. Đỗ Trung Đàm (2006), Phương pháp ngoại suy liều có hiệu quả tương đương giữa người và động vật thí nghiệm. Phương pháp nghiên cứu tác dụng dược lý của thuốc từ dược thảo. Nhà xuất bản khoa học và kỹ thuật. Tạp chí dược học, số 479, tr. 38-41
3. Hoàng Bảo Châu (1997). Chứng Tý. Nội khoa y học cổ truyền, Nhà xuất bản Y học, Hà Nội, trang 574 – 585
4. Li Meihan, Xiao Rong, Li Jing et al. (2017). Regenerative approaches for cartilage repair in the treatment of osteoarthritis. Osteoarthritis and Cartilage, 25(10), 1577-1587.
5. Joon-Ki Kim, Sang-Won Park, Jung-Woo Kang et al (2012). Effects of GSCB- 5, a Herbal Forrmulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Evidence-Based Complementary and Alternative Medicine, Vol 2012, doi: 10.1155/2012/730907
6. F.J. Al-Safar, S. Ganabadi, H. Yaakub et al (2009), “Collagenase and Sodium Iodoacetate – Induced experimental Osteoarthritis Model in Sprague Dawley Rats”, Asian Journal of Scientific Research 2(4): 167-179.
7. Wu Liu-Qing et al. (2016). Antinociceptive Effects of Prim-O- Glucosylcimifugin in Inflammatory Nociception via Reducing Spinal COX-2.Biomolecules & Therapeutics,24(4),418-25.
8. Li, X., Wang, J., & Gao, L. (2013). Anti-inflammatory and analgesic activity of R.A.P. (Radix Angelicae Pubescentis) ethanol extracts. African journal of traditional, complementary, and alternative medicines, 10 (3), 422-6.
9. Choi YY., Kim MH., Han JM at al (2014). The anti-inflammatory potential of Cortex Phellodendron in vivo and in vitro: down-regulation of NO and iNOS through suppression of NF-κB and MAPK activation. The Immunopharmacol., 19(2), 214-20
10. Xiaokun Jiang (2014). Extraction and analgesic effects of polysaccharides from Achyranthes bidentata Blume. Applied Mechanics and Materials, 675-677, 1600-1603.