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ASSOCIATION BETWEEN AZF DELETION MUTATION AND SEMEN PARAMETERS IN OLIGOZOOSPERMIC MEN AT HANOI MEDICAL UNIVERSITY HOSPITAL
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Abstract
Objective: Evaluating the prevalence of AZF deletion mutations and the relationship between AZF deletion mutations with semen parameters and other factors in oligospermic men. Material and methods: Retrospective, cross-sectional study conducted on 243 oligospermic men who were tested with Multiplex PCR to determine AZF mutations at Hanoi Medical University Hospital. Results: AZF deletion mutation has 47 cases (19.3%), of which 5/47 cases (10.6%) have AZFb deletion mutation, 27/47 cases (57.5%) of AZFc deletion mutations and 15/47 (31.9%) cases with combined AZFb and AZFc deletion mutations. No AZFa mutation was detected. The average values of the parameters of semen characteristics and male sex hormones between the AZF mutation and non-mutation groups were not statistically different (p > 0.05). Conclusion: There is no difference in semen parameters and male sex hormones between men with and without AZF deletion mutation.
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Keywords
AZF, semen analysis, oligospermia
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