MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ HÌNH ẢNH TỔN THƯƠNG TRÊN PHIM CHỤP CỘNG HƯỞNG TỪ Ở BỆNH NHÂN NGỘ ĐỘC KHÍ N2O ĐIỀU TRỊ TẠI TRUNG TÂM CHỐNG ĐỘC

Abstract

Objectives: To describe clinical characteristics, laboratory findings, and treatment results on patients with N₂O toxicity admitted to the Poison Control Center, Bach Mai Hospital from 2022-2023. Subjects and methods: A cross-sectional descriptive, recovery study on 32 people diagnosed with N₂O poisoning from April 2022 to April 2023 at the Poison Control Center, Bach Mai Hospital. Results: The most common neurological and psychiatric symptoms and signs were numbness (96,9%), limb weakness (59,4%), hypoesthesia (34,4%), and behavior change (12,5%). The median plasma concentrations of homocystein experienced a climb (80,29 ± 17,93 μmol/L) while the figure for vitamin B12 was in the normal reference range (304,55 ± 83,01 pmol/L). In MRI, most lesions were located on the cervical spinal cord, especially from C3 to C6 (C3: 40%, C4: 45%, C5: 45%, C6: 30.1%), followed by lesions on the thoracic spinal cord (< 20%) and lesions in the lumbar spine (< 5%). Spinal cord injury with inverted - V sign was found in 14 patients, accounting for 75%. Vitamin B12 concentration in patients having inverted - V sign on spinal MRI higher than that of patients without this sign. Symptoms improved significantly after treatment. Conclusion: N₂O poisoning causes neurological and psychiatric symptoms, MRI’s typical lesion is the inverted - V sign related to vitamin B12 reduction