NGHIÊN CỨU TÁC DỤNG CỦA VIÊN NANG CỨNG TD0070 LÊN CÁC CHỈ SỐ MIỄN DỊCH TẾ BÀO VÀ MIỄN DỊCH DỊCH THỂ TRÊN THỰC NGHIỆM

Abstract

Research objective: Research on the effects of TD0070 hard capsules on cell-mediated and humoral immunity indices in white mice. Subjects and methods: Swiss white mice, purebred, both breeds, weighing 20±2 g. Research on the effects of TD0070 hard capsules on cell-mediated and humoral immune indices in white mice using intraperitoneal injection of cyclophosphamide causing immunodeficiency. Result: OA skin reaction: TD0070 oral doses of 1.728 g/kg and 3.456 g/kg: Skin reactions tend to increase compared to the model lot, but the difference is not statistically significant ( p > 0.05). Peripheral blood cytokine concentration: in the batch taking TD0070 at a dose of 1.728 g/kg, the concentrations of IL-2 and IFN-α in the peripheral blood increased significantly compared to the model batch with p < 0.05. TNF-α and IFN-γ concentrations tended to increase compared to the model batch, but the difference was not statistically significant (p > 0.05). At TD0070 oral dose of 3.456 g/kg: The concentration of cytokines in peripheral blood tends to increase compared to the model batch, however, the difference is not statistically significant (p > 0.05), except TNF-α increased significantly compared to the model batch with p < 0.01. IgG concentration in peripheral blood increased significantly compared to the model batch with p < 0.01 and p < 0.001, respectively. Conclusion: TD0070 dose of 1.728/kg (equivalent to the expected therapeutic dose in humans) taken continuously for 7 days has a clear immunostimulating effect on the model of acute immunodeficiency caused by cyclophosphamide through the Indicators: OA skin reaction, concentrations of IL-2, IFN-α, TNF-α, IFN-γ and IgG in peripheral blood. TD0070 dose of 3.456 g/kg tends to have better immunostimulatory effects in OA skin reaction, TNF-α concentration, IgG concentration in peripheral blood.