TỶ LỆ LƯU HÀNH TÝP VI RÚT DENGUE GÂY SỐT XUẤT HUYẾT TẠI BỆNH VIỆN THÀNH PHỐ THỦ ĐỨC

Abstract

Background: Dengue hemorrhagic fever (DHF) is an acute infectious disease caused by the Dengue virus and it still has no specific medicine or effective vaccine to prevent the disease. Therefore, determining the circulation rate of these virus types will help identifying, monitoring, and preventing the disease more effectively. Objectives: (1) Determine the rate of Dengue virus types in patients suffering from Dengue hemorrhagic fever at Thu Duc City Hospital. (2) Determine the relationship between this virus type and age, gender, and severity of illness. Subjects and Methods: Descriptive cross-sectional study was conducted from October 2022 - August 2023 on 332 patients who came for treatment at Thu Duc City Hospital to be diagnosed with Dengue hemorrhagic fever and required to do a quick NS1, IgM, IgG test for screening. Then they did an RT-realtime PCR test to determine the Dengue virus type. Results: In the study, out of the 332 qualified patients, there were 175 male and 157 female. RT-realtime PCR test detected and identified the type of Dengue virus in 252 patients including 133 male (52.8%), 119 female (47.2%) with the following percentage of serotypes: DENV -1 (27%), DENV-2 (64.3%), DENV-4 (6.7%), DENV-1&2 (2%) and none of DENV-3 was identified. DENV-2 type accounts for a much higher rate than other types in terms of age groups, gender and severity. Dengue virus types record different levels including: a low level of mild Dengue disease (88.5%), Dengue fever with warning signs (10.7%) and a few severe Dengue one (0.8%). Conclusion: Determine the circulation of Dengue virus type includes DENV-2 (64.3%), DENV-1 (27%), DENV-4 (6.7%) and a co-infected Dengue virus type: DENV-1&2 (2%). There is no relationship between Dengue virus type and age, gender. DENV-2 type has a higher risk of Dengue with warning signs and severity than other virus types.