SOME FACTORS RELATED TO THE LEVEL OF FATALITIES LIVER IN PATIENTS WITH TYPE 2 DIABETES AT NGHE AN FRIENDSHIP GENERAL HOSPITAL

Công Long Nguyễn, Phú Tài Lê, Thị Hoa Lê, Thị Ngọc Hà Đoàn, Văn Hiếu Nguyễn

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Abstract

Objective: Survey factors related to the level of non-alcoholic fatty liver disease in patients with type 2 diabetes at Nghe An General Friendship Hospital from July 2022 to June 2023. Subjects and methods: 262 patients with type 2 diabetes were diagnosed with non-alcoholic fatty liver disease based on clinical and ultrasound results. All patients have exploited information about general characteristics, clinical manifestations, and blood tests. Results: Among 262 patients, there was mainly level I fatty liver with 82.4%, followed by level II with 16%, and only 4 with level III. The degree of fatty liver is related to BMI (BMI ≥ 23, OR=2.6, p=0.02), triglyceride concentration (Triglyceride ≥ 1.7 mmol/l, OR=2.3, p=0.01), LDL-C concentration (LDL-C ≥ 1.03 mmol/l, OR=2.6, p=0.02). There was no difference between the degree of fatty liver and age, gender, medical history, metabolic syndrome, total cholesterol concentration, AST, and ALT. Conclusion: BMI, triglyceride levels, and LDL-C levels are related to the degree of fatty liver

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References

1. Younossi ZM, Golabi P, de Avila L, et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis. Journal of hepatology. 2019;71(4):793-801.
2. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328-357.
3. Trần Thị Khánh Tường. Yếu tố nguy cơ dự đoán xơ hóa gan tiến triển trên bệnh nhân đái tháo đường type 2 bị bệnh gan nhiễm mỡ không do rượu. Tạp chí Y dược lâm sàng 108. 2020;15(4):67-72.
4. Asia Muhammad N. Non-Alcoholic Fatty Liver Disease, an Overview. Integr Med (Encinitas). 2019;18(2):42-49.
5. Chitturi S, Farrell GC, Hashimoto E, et al. Non‐alcoholic fatty liver disease in the Asia–Pacific region: Definitions and overview of proposed guidelines. Journal of gastroenterology and hepatology. 2007;22(6):778-787.
6. Trang VTT. Nghiên cứu đặc điểm lâm sàng, một số xét nghiệm, siêu âm và mô bệnh học bệnh gan nhiễm mỡ. Luận án Tiến sỹ y học. Hà Nội, Viện Nghiên cứu Khoa học Y Dược lâm sàng 108; 2019.
7. Noureddin M, Lam J, Peterson MR, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013;58(6):1930-1940.
8. Seto WK, Yuen MF. Nonalcoholic fatty liver disease in Asia: emerging perspectives. Journal of gastroenterology. 2017;52(2):164-174.