SURVEY OF FACTORS RELATED TO HYPOKALEMIA IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AT CHO RAY HOSPITAL

Phi Hùng Trương

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Abstract

Introduction: Acute myocardial infarction often leads to dangerous arrhythmias in the early hours, especially ventricular tachycardia and ventricular fibrillation. Electrolyte disturbances, particularly hypokalemia, are associated with ventricular arrhythmias. However, in Vietnam, research on hypokalemia in patients with acute myocardial infarction is still limited. Objective: Identifying factors related to hypokalemia in patients with acute myocardial infarction. Subjects: Patients with acute myocardial infarction admitted to the Interventional Cardiology Department at Cho Ray Hospital from May 2023 to September 2023. Study design: Cross-sectional study description. Results: The study enrolled 155 acute myocardial infarction patients with an average age of 65.1 ± 12.1 and a male predominance (71.6%). Common comorbidities included hypertension (69.7%), diabetes mellitus (38.2%), dyslipidemia (41.3%), and chronic coronary syndrome (21.9%). The usage rates of medications with the potential to lower potassium were diuretics (16.8%), insulin (11.6%), and beta-2 agonists (5.2%). The prevalence of hypokalemia in the population was 34.2%, with mild hypokalemia being the most common (64.2%), followed by moderate hypokalemia (28.3%), and severe hypokalemia at 7.5%. Two clinical factors associated with hypokalemia in the study were vomiting (OR 2.86, 95% CI 1.17–6.97) and the use of potassium-wasting diuretics (OR 2.99, 95% CI 1.12–7.92). Conclusion: The incidence of hypokalemia in acute myocardial infarction patients is 34.2%, with the majority experiencing mild hypokalemia. Vomiting and the use of potassium-wasting diuretics are two factors identified as being associated with hypokalemia.

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References

1. Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal. 2018;39(2):119-177. doi:10.1093/eurheartj/ehx393
2. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. European heart journal Acute cardiovascular care. Feb 2017;6(1):18-25. doi:10.1177/2048872615624241
3. Colombo MG, Kirchberger I, Amann U, Dinser L, Meisinger C. Association of serum potassium concentration with mortality and ventricular arrhythmias in patients with acute myocardial infarction: A systematic review and meta-analysis. European Journal of Preventive Cardiology. 2018;25(6): 576-595. doi:10.1177/ 2047487318759694
4. Trần Việt A, Phạm Mạnh H. Khảo sát tình trạng điện giải máu lúc nhập viện ở bệnh nhân nhồi máu cơ tim cấp tại Viện Tim mạch - Bệnh viện Bạch Mai. Tạp chí Tim mạch học Việt Nam. 06/01 2019;(88):83-89.
5. Goyal A, Spertus JA, Gosch K, et al. Serum potassium levels and mortality in acute myocardial infarction. Jama. Jan 11 2012;307(2):157-64. doi:10.1001/jama.2011.1967
6. Ravn Jacobsen M, Jabbari R, Glinge C, et al. Potassium Disturbances and Risk of Ventricular Fibrillation Among Patients With ST-Segment-Elevation Myocardial Infarction. Journal of the American Heart Association. Feb 18 2020;9(4):e014160. doi:10.1161/jaha.119.014160
7. Shilpa Patil SG, Piyush Prajapati, Shivraj Afzalpurkar, Omkar Patil, Mohit Khatri. A study of electrolyte imbalance in acute myocardial infarction patients at a tertiary care hospital in western Maharashtra. International Journal of Contemporary Medical Research 2016;3(12): 3568-3571.