MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG CỦA BỆNH NHÂN UNG THƯ PHỔI BIỂU MÔ TUYẾN DI CĂN NÃO CÓ ĐỘT BIẾN EGFR TẠI BỆNH VIỆN K

Abstract

Objective: Description of some clinical and subclinical features of patients adenocarcinoma of lung have brain metastasis with EGFR mutation at Vietnam National Cancer Hospital. Patients and methods: Cross-sectional descriptive study on 66 patients adenocarcinoma of lung have brain metastasis with EGFR mutations (exon 19 deletion and L858R point mutation exon 21) were treated with first- generation TKIs at Vietnam National Cancer Hospital from October 2015 to January 2021. Results: The average age is 55 ± 10,6 years old, smoker/non smoker = ½, male/female = 1/1. Most patients have good physical condition (PS 0-1 = 89%). Most common symptom are prolonged cough (45,5%), chest pain (42,4%), dyspnea (19,7%) and headache (18,2%). The symptom of brain metastasis are intracranial hypertension (31,8%), weakness (6,1%), cranial nerve paralysis (1,5%) and seizures (4,5%). Almost size of primary tumor in range 3-7cm. Characteristics of brain metastatic leisons: most common are 2-3 leisons with lengths 1,1-2cm. The most common sites of extracerebral metastases are bone and pleura. Conclusion: The average age of the patients is 55 ± 10,6 years old, most patients are in good health, prolonged- cough is the most common symptom. Increased intracranial pressure is the most common neurological symptom. Most patients have metastases both in the brain and outside the brain.