KHẢO SÁT HOẠT ĐỘ LIPASE VÀ MỘT SỐ XÉT NGHIỆM LIÊN QUAN Ở BỆNH NHÂN VIÊM TỤY CẤP TẠI BỆNH VIỆN ĐẠI HỌC Y DƯỢC THÀNH PHỐ HỒ CHÍ MINH

Abstract

Background: Acute pancreatitis is an acute inflammation of the pancreas, commonly triggered by gallstones or alcohol consumption. Lipase is an enzyme secreted by the pancreas. Blood lipase levels rise earlier and remain elevated longer (8-14 days) compared to blood amylase levels. The specificity of lipase in acute pancreatitis is over 95% and sensitivity ranges from 55 - 100%. These large studies suggest that lipase is a better marker for diagnosing acute pancreatitis. Objectives: Measure serum lipase levels and determine the sensitivity and specificity of the lipase test in diagnosing acute pancreatitis. Methods: Cross-sectional descriptive study. 242 patients were diagnosed with acute pancreatitis and admitted to the Emergency Department in University Medical Center at Ho Chi Minh City from January 2021 to August 2023. Results: The average age of the study group was 50,1 ± 16,7 years old, the male/female ratio was 2,06/1. Lipase values in the 3 groups of Mild acute pancreatitis, Moderately severe acute pancreatitis, Severe acute pancreatitis were 680,6 (369,2-1185,8), 906,8 (394,6-1714,5); 1800,0 (689,2-2823,5) respectively. There was a statistically significant difference in lipase levels between the three groups (p < 0.001). The sensitivity and specificity of lipase at 2-fold above normal limit  were 97,9% and 93,8%; J coefficient = 0,917;  The sensitivity and specificity of lipase at 3-fold above normal limit were 97,1% and 97,5%; J coefficient = 0,946. Conclusion: In this study, lipase index was very valuable in diagnosing acute pancreatitis. The sensitivity and specificity of lipase at 3-fold above normal limit is the best